Targeting maladaptive glutathione responses in lung disease
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Summary
This commentary will focus on glutathione (GSH) as a key antioxidant in the lung airways and discuss mechanisms by which the lung uses GSH to adapt to its rapidly changing environment.
- Type
- article
- Published
- 2010-10-14
- Cited by
- 44
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964944695
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3180690
Keywords
Lung, Glutathione, Lung disease, Inflammation, Reactive oxygen species
References
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- Infection and inflammation in cystic fibrosis: a short review.
- L-gamma-Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)?
- The systemic availability of oral glutathione
- Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease.
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- Superoxide dismutases in the lung and human lung diseases.
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- The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.
- Exogenous glutathione protects intestinal epithelial cells from oxidative injury.
- Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
Cited by
- 5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects
- Modulation of Respiratory Tract Responses by Acetaminophen
- Effect of N‐acetylcysteine supplementation on oxidative stress status and alveolar inflammation in people exposed to asbestos: A double‐blind, randomized clinical trial
- Acute and subchronic exposure to air particulate matter induces expression of angiotensin and bradykinin-related genes in the lungs and heart: Angiotensin-II type-I receptor as a molecular target of particulate matter exposure
- CFTR is the primary known apical glutathione transporter involved in cigarette smoke induced adaptive responses in the lung
- A Synthetic Chalcone as a Potent Inducer of Glutathione Biosynthesis
- Attempts to counteract phosgene-induced acute lung injury by instant high-dose aerosol exposure to hexamethylenetetramine, cysteine or glutathione
- Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance
- Lung glutathione adaptive responses to cigarette smoke exposure
- Redox-Based Regulation of Apoptosis: S-Glutathionylation As a Regulatory Mechanism to Control Cell Death
- Macropinocytosis of Extracellular Glutathione Ameliorates Tumor Necrosis Factor α Release in Activated Macrophages
- Glutathione Depletion Accelerates Cigarette Smoke-Induced Inflammation and Airspace Enlargement.
- Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study
- Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol‐antioxidants
- Phosgene-induced acute lung injury (ALI): differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine
- Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines.
- N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why
- Oxidative Toxicology of Bleomycin: Role of the Extracellular Redox Environment
- Extracellular vesicles as mediators of the response to respiratory exposures
- In vivo and in vitro evidence for the involvement of Nrf2-antioxidant response element signaling pathway in the inflammation and oxidative stress induced by particulate matter (PM10): the effective role of gallic acid
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