Liver Fibrosis, but no Other Histologic Features, Associates with Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
Explore this paper's citation graph
Summary
In a longitudinal study of patients with NAFLD, fibrosis stage, but no other histologic features of steatohepatitis, were independently associated with long-term overall mortality, liver transplantation, and liver-related events.
- Type
- article
- Published
- 2015-04-29
- Cited by
- 2,689
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964572117
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7788704
Keywords
Nonalcoholic fatty liver disease, Fibrosis, Medicine, Fatty liver, Gastroenterology
References
- Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings
- Clinical trials: Trial design in NASH—realities and challenges
- Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace.
- Long‐term follow‐up of patients with NAFLD and elevated liver enzymes
- Cryptogenic cirrhosis: Clinical characterization and risk factors for underlying disease
- The natural history of nonalcoholic fatty liver disease: a population-based cohort study.
- Prevalence and Indicators of Portal Hypertension in Patients with Nonalcoholic Fatty Liver Disease
- Diagnosing steatohepatitis and predicting liver‐related mortality in patients with NAFLD: Two distinct concepts
- THE NATURAL HISTORY OF NONALCOHOLIC FATTY LIVER DISEASE WITH ADVANCED FIBROSIS OR CIRRHOSIS: AN INTERNATIONAL COLLABORATIVE STUDY
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- Design and validation of a histological scoring system for nonalcoholic fatty liver disease
- Portal Chronic Inflammation in Nonalcoholic Fatty Liver Disease
- ENDPOINTS AND CLINICAL TRIAL DESIGN FOR NONALCOHOLIC STEATOHEPATITIS
- Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver‐related mortality
- Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease
- Portal inflammation is associated with advanced histological changes in alcoholic and non-alcoholic fatty liver disease
- Management of hepatocellular carcinoma: An update
- Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension.
- Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease
- Liver Transplantation for Nonalcoholic Steatohepatitis: The New Epidemic
Cited by
- Noninvasive Assessment of Nonalcoholic Steatohepatitis and Nonalcoholic Steatohepatitis-Related Fibrosis: Is There a Role for Cytokeratin 18?
- Nonalcoholic fatty liver disease
- Binge-Eating Disorder in Adults
- Using a 3% Proton Density Fat Fraction as a Cut-Off Value Increases Sensitivity of Detection of Hepatic Steatosis, Based on Results From Histopathology Analysis.
- A Molecular Signature of Mouse NASH: A Step Closer to a Human Predictive Biomarker?
- Animal models of NAFLD from a hepatologist's point of view.
- A practical clinical approach to liver fibrosis.
- Association of low skeletal muscle mass with advanced liver fibrosis in patients with non‐alcoholic fatty liver disease
- Hepatic Steatosis in Lean Patients: Risk Factors and Impact on Mortality
- Serum levels of immunoglobulin M‐free inhibitors of macrophage/CD5L as a predictive and early diagnostic marker for nonalcoholic steatohepatitis‐associated hepatocellular carcinoma
- Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study
- The Hierarchical Model of NAFLD: Prognostic Significance of Histologic Features in NASH.
- Nonalcoholic fatty liver disease: a systematic review.
- Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease.
- Non-alcoholic fatty liver disease
- Caring for children with NAFLD and navigating their care into adulthood
- Nonalcoholic Fatty Liver Disease Review: Diagnosis, Treatment, and Outcomes.
- Natural antioxidants for non‐alcoholic fatty liver disease: molecular targets and clinical perspectives
- High prevalence of hepatic fibrosis in the setting of coexisting diabetes and hepatic steatosis: A case for selective screening in the general population?
- Hepatitis C Virus Infection Is Associated With Increased Cardiovascular Mortality: A Meta-Analysis of Observational Studies.
Related papers
- Aldafermin quantitatively improves inflammation in a 24-week clinical trial in patients with nonalcoholic steatohepatitis
- Correction of endotoxemia in patients with nonalcoholic steatohepatitis
- 594 Antioxidant vitamin E prevents the development of nonalcoholic steatohepatitis (NASH) in rats
- 10.1016/s1558-0164(09)70387-6
- Efficacy of Ganzaoning granules on the patients with nonalcoholic steatohepatitis
- Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis
- Gd-EOB-DTPA-enhanced-MR imaging in the inflammation stage of nonalcoholic steatohepatitis (NASH) in mice.
- Prof Jörn Schattenberg sheds light on key treatment and diagnostic approaches to nonalcoholic steatohepatitis (NASH)