The Topoisomerase-related Function Gene TRF4 Affects Cellular Sensitivity to the Antitumor Agent Camptothecin*
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Summary
It is reported here that two genes required for sister chromatid cohesion,TRF4 and MCD1/SCC1, are also required to repair camptothecin-mediated damage to DNA and it is shown that Trf4 is a nuclear protein whose expression is cell cycle-regulated at a post-transcriptional level.
- Type
- article
- Published
- 1999-03-12
- Cited by
- 74
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964370455
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18120428
Keywords
Camptothecin, Topoisomerase, Function (biology), Gene, Sensitivity (control systems)
References
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- DNA renaturation activity of the SMC complex implicated in chromosome condensation
- Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I.
- A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.
- Genetic analysis of benign, low-grade, and high-grade ovarian tumors.
- Yeast as a genetic model system for studying topoisomerase inhibitors.
- Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.
- A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae.
- SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I.
- Biochemical and genetic dissection of mitotic chromosome condensation.
- Cyclin is degraded by the ubiquitin pathway
- Cellular Resistance to Camptothecins
- A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B.
- Camptothecin Sensitivity Is Mediated by the Pleiotropic Drug Resistance Network in Yeast*
- ATP-dependent positive supercoiling of DNA by 13S condensin: a biochemical implication for chromosome condensation.
- Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2
- DNA topoisomerase-targeting antitumor drugs can be studied in yeast.
Cited by
- Contribution of Trf4/5 and the Nuclear Exosome to Genome Stability Through Regulation of Histone mRNA Levels in Saccharomyces cerevisiae
- Inferring tumor evolution using computational phylogenetics
- Yeast nuclear RNA processing.
- Cytoplasmic polyadenylation in S. pombe
- Repair of topoisomerase I-mediated DNA damage.
- The cohesin complex: sequence homologies, interaction networks and shared motifs
- Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.
- Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex
- Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair.
- Inference of Tumor Phylogenies from Genomic Assays on Heterogeneous Samples
- Recurrent mutations in the deafness geneGJB2 (connexin 26) in British Asian families
- Trf4 is a useful gene for discrimination of Candida tropicalis from other medically important Candida species.
- Current perspectives on the role of TRAMP in nuclear RNA surveillance and quality control
- Replication-related activities establish cohesion between sister chromatids
- Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7.
- Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes.
- Semi-quantitative fluorescent PCR analysis identifies PRKAA1 on chromosome 5 as a potential candidate cancer gene of cervical cancer.
- Histone Tail-independent Chromatin Binding Activity of Recombinant Cohesin Holocomplex*
- Determination of the ‘critical region’ for cat-like cry of Cri-du-chat syndrome and analysis of candidate genes by quantitative PCR
- Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest
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