Contribution of Trf4/5 and the Nuclear Exosome to Genome Stability Through Regulation of Histone mRNA Levels in Saccharomyces cerevisiae
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Summary
It is shown that loss of Trf4 and Trf5, or of Rrp6, a component of the nuclear exosome, results in elevated levels of transcripts encoding DNA replication-dependent histones, suggesting that increased histone levels account for the phenotypes of trf mutants.
- Type
- article
- Published
- 2007-03-01
- Cited by
- 71
- References
- 97
- Access
- Open access
- OpenAlex
- https://openalex.org/W17179095
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19258805
Keywords
Political science, Art
References
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- The Topoisomerase-related Function Gene TRF4 Affects Cellular Sensitivity to the Antitumor Agent Camptothecin*
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- Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.
Cited by
- The exozyme model: a continuum of functionally distinct complexes.
- The PolyA tail length of yeast histone mRNAs varies during the cell cycle and is influenced by Sen1p and Rrp6p
- Yeast nuclear RNA processing.
- RNA-protein crosslinking identifies novel targets for the nuclear RNA surveillance machinery
- Lsm1 promotes genomic stability by controlling histone mRNA decay
- WEE1 Tyrosine Kinase, A Novel Epigenetic Modifier
- DNA repair pathways as targets for cancer therapy
- Excess histone levels mediate cytotoxicity via multiple mechanisms
- Dpb2p, a Noncatalytic Subunit of DNA Polymerase ε, Contributes to the Fidelity of DNA Replication in Saccharomyces cerevisiae
- Current perspectives on the role of TRAMP in nuclear RNA surveillance and quality control
- Regulation of histone gene transcription in yeast
- Exosome-mediated quality control: substrate recruitment and molecular activity.
- Yeast lsm pro-apoptotic mutants show defects in S-phase entry and progression
- The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing
- Mechanisms of genome instability induced by RNA processing defects
- Histone modifications: cycling with chromosomal replication.
- Eri1: A Conserved Enzyme at the Crossroads of Multiple RNA Processing Pathways
- Histone tyrosine phosphorylation comes of age
- Deletion of the nuclear exosome component RRP6 leads to continued accumulation of the histone mRNA HTB1 in S-phase of the cell cycle in Saccharomyces cerevisiae
- Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control
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