Contribution of Trf4/5 and the Nuclear Exosome to Genome Stability Through Regulation of Histone mRNA Levels in Saccharomyces cerevisiae

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Summary

It is shown that loss of Trf4 and Trf5, or of Rrp6, a component of the nuclear exosome, results in elevated levels of transcripts encoding DNA replication-dependent histones, suggesting that increased histone levels account for the phenotypes of trf mutants.

Type
article
Published
2007-03-01
Cited by
71
References
97
Access
Open access

Keywords

Political science, Art

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