Natural Killer Cell Education and Tolerance
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Summary
The major mechanisms of NK cell education and tolerance are reviewed, including inhibitory receptors for self-MHC class I, self-molecules, and other tolerance mechanisms.
- Type
- review
- Published
- 2010-09-17
- Cited by
- 433
- References
- 88
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964265426
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16378910
Keywords
Biology, NK-92, Major histocompatibility complex, Interleukin 21, Lymphokine-activated killer cell
References
- Breaking tolerance to self, circulating natural killer cells expressing inhibitory KIR for non-self HLA exhibit effector function after T cell-depleted allogeneic hematopoietic cell transplantation.
- Natural killer cell tolerance licensing and other mechanisms.
- Effect of NKG2D ligand expression on host immune responses
- Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis1
- Impact of natural killer cell dose and donor killer‐cell immunoglobulin‐like receptor (KIR) genotype on outcome following human leucocyte antigen‐identical haematopoietic stem cell transplantation
- Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice.
- Specific and nonspecific NK cell activation during virus infection
- Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
- The basis for self-tolerance of natural killer cells in beta2-microglobulin- and TAP-1- mice.
- NK Cell Responsiveness is Tuned Commensurate with the Number of Inhibitory Receptors for Self MHC Class I: the Rheostat Model
- Interactions of Ly49 Family Receptors with MHC Class I Ligands in trans and cis1
- Class I-deficient hemopoietic cells and nonhemopoietic cells dominantly induce unresponsiveness of natural killer cells to class I-deficient bone marrow cell grafts.
- Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
- Missing self recognition by natural killer cells in MHC class I transgenic mice. A 'receptor calibration' model for how effector cells adapt to self.
- Improved survival with inhibitory Killer Immunoglobulin Receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation
- Up on the tightrope: natural killer cell activation and inhibition
- MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response.
- NK cell education: not an on-off switch but a tunable rheostat.
- Adaptive Immune Features of Natural Killer Cells
- Licensing of natural killer cells by self‐major histocompatibility complex class I
Cited by
- Etude des mécanismes régulateurs des cellules NK : rôle de la molécule PD-1 et de la prostaglandine E2 (PGE2)
- Role of NK cells in DC-based immunotherapy of melanoma
- The Role of Natural Killer Cells in Autoimmunity
- Immunogenicity of in vitro maintained and matured populations: potential barriers to engraftment of human pluripotent stem cell derivatives
- In vitro determination and functional maturation of natural killer cells from umbilical cord blood progenitor cells
- Immunological mechanisms of tumour progression. The rationale for natural killer cell based immunotherapy for glioblastoma
- Polymorphisme du gène NCR3/NKp30 et variabilité de la fonction des cellules Natural Killer humaines
- KIR and HLA under pressure: evidences of coevolution across worldwide populations
- Interferon-gamma Mediated Host Responses to Enteric Pathogen, Citrobacter rodentium
- Chimpanzee susceptibility to hepatitis C virus infection correlates with presence of Pt-KIR3DS2 and Pt-KIR2DL9: paired activating and inhibitory natural killer cell receptors
- Transcriptional Control of NK Cells.
- microRNA management of NK cell developmental and functional programs
- Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression
- “Adherent” versus Other Isolation Strategies for Expanding Purified, Potent, and Activated Human NK Cells for Cancer Immunotherapy
- Irradiation and bone marrow reconstitution affect the functional Ly49 natural killer cell repertoire in rats
- The immunology of early pregnancy in farm animals.
- Development of natural killer cells regulated by T-box transcription factors
- The Role of Natural Killer Cells in Alzheimer’s Disease
- The T cell repertoire specific for the IE-1 protein of human cytomegalovirus
- Failure recovery of circulating NKG2D+CD56dimNK cells in HBV-associated hepatocellular carcinoma after hepatectomy predicts early recurrence
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