Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity.
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Summary
The data suggest that microglia express functional serotonin receptors linked to distinct microglial properties as serotonin deficiency not only has been linked to a number of psychiatric disease like depression and anxiety but may also permeate from the periphery through blood-brain barrier openings seen in neurodegenerative disease.
- Type
- article
- Published
- 2012-03-01
- Cited by
- 161
- References
- 52
- OpenAlex
- https://openalex.org/W1964223116
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23260010
Keywords
Microglia, Serotonin, CX3CR1, Receptor, 5-HT receptor
References
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Cited by
- Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypes
- Integrating the monoamine, neurotrophin and cytokine hypotheses of depression--a central role for the serotonin transporter?
- Neuronal-glial mechanisms of exercise-evoked stress robustness.
- Placenta-derived hypo-serotonin situations in the developing forebrain cause autism.
- Serotonin & developmental axonal refinement : microglia contribution ?
- Altered microglial phagocytosis in GPR34‐deficient mice
- The effect of serotonin–noradrenaline reuptake inhibitor duloxetine on the intervertebral disk-related radiculopathy in rats
- The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon‐γ, and IL‐4
- Neurotransmitter and neurohormone receptors on microglia
- Mikroglia als Vermittler immuno-logischer Aspekte der Depression
- Microglia in development: linking brain wiring to brain environment.
- The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer’s disease
- Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
- Microglia: new roles for the synaptic stripper.
- Clozapine and olanzapine inhibit proton currents in BV2 microglial cells.
- Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections.
- Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson’s disease
- Neuroendocrine Signaling Via the Serotonin Transporter Regulates Clearance of Apoptotic Cells*
- Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies
- Increasing brain serotonin corrects CO2 chemosensitivity in methyl-CpG-binding protein 2 (Mecp2)-deficient mice
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