The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.
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Summary
It is concluded that the JH7-6 domains of JAK3 are necessary and sufficient for gammac association and may provide a target for the development of novel therapeutic modalities in immunologically mediated diseases.
- Type
- article
- Published
- 1997-06-24
- Cited by
- 162
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964220962
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11048417
Keywords
Janus kinase 3, Common gamma chain, Biology, Cytokine receptor, Mutant
References
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- JAK2, a third member of the JAK family of protein tyrosine kinases.
- The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
- Utilization of the beta and gamma chains of the IL‐2 receptor by the novel cytokine IL‐15.
- Signal transduction mediated by the reconstituted IL-2 receptor. Evidence for a cell type-specific function of IL-2 receptor beta-chain.
- A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6.
- A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells
- JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
- A protein tyrosine kinase in the interferon alpha/beta signaling pathway.
- Cytokine signaling through nonreceptor protein tyrosine kinases.
- Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.
- JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.
- Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.
- Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
- The Conserved Box 1 Motif of Cytokine Receptors Is Required for Association with JAK Kinases (*)
- The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.
- Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
Cited by
- Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?
- TEL-JAK2 transgenic mice develop T-cell leukemia.
- Non-receptor protein tyrosine kinases.
- Advances in the Understanding of Cytokine Signal Transduction: The Role of Jaks and STATs in Immunoregulation and the Pathogenesis of Immunodeficiency
- Impact of interferon β and interferon stimulated gene induction on Bunyamwera virus replication
- RNA virus modulation of IFN, PI3K and apoptosis
- Investigation of the role of haematopoietic cell kinase in normal and leukaemic haematopoiesis
- Recent Advances in the Understanding of Interleukin-2 Signal Transduction
- The role of Janus Kinase 3 in CD4+ T Cell Homeostasis and Function: A Dissertation
- analyses of 10 patients and outcomes of stem cell transplantation Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular
- Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.
- L'hormone de croissance : une cytokine
- CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Disseminated
- Jak3 and the pathogenesis of severe combined immunodeficiency.
- Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.
- IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells.
- IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2.
- The JAK/STAT pathway and Drosophila development
- General mechanisms of cytokine receptor signaling.
- Biology of the interleukin-2 receptor.
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