Activation‐induced cytidine deaminase induces DNA break repair events more frequently in the Ig switch region than other sites in the mammalian genome

Keywords

Cytidine deaminase, Somatic hypermutation, Biology, Immunoglobulin class switching, Activation-induced (cytidine) deaminase

References

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• Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line1Jürgen Bachl, Chris Carlson, Vanessa C. Gray‐Schopfer — 2001
• Analysis of a hot spot for DNA insertion suggests a mechanism for Ig switch recombination.Joseph Baar, Nancy Pennell, M J Shulman — 1996
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• Mechanisms of double-strand-break repair during gene targeting in mammalian cells.Philip Ng, Mark D. Baker — 1999
• Capture of DNA sequences at double-strand breaks in mammalian chromosomes.Yunfu Lin, Alan S. Waldman — 2001
• Non‐redundancy of cytidine deaminases in class switch recombinationSebastian D. Fugmann, James S. Rush, David G. Schatz — 2004
• AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switchingSimone Petersen, Rafael Casellas, Bernardo Reina‐San‐Martin — 2001
• Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations.Michael R. Lieber, Kefei Yu, Sathees C. Raghavan — 2006
• Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a)Melinda S. Gordon, Cindy M. Kanegai, Jeanette R. Doerr — 2003
• R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cellsKefei Yu, Frédéric Chédin, Chih-Lin Hsieh — 2003
• The AID enzyme induces class switch recombination in fibroblastsIl‐mi Okazaki, Kazuo Kinoshita, Masamichi Muramatsu — 2002
• Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.Andrew Peters, Ursula Storb — 1996
• Emerging links between hypermutation of antibody genes and DNA polymerasesPatricia J. Gearhart, Richard D. Wood — 2001
• Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line.Mark D. Baker, Nancy Pennell, Lucine Bosnoyan — 1988

Cited by

• AID constrains germinal center size by rendering B cells susceptible to apoptosis.Ahmad Zaheen, Bryant Boulianne, Jahan‐Yar Parsa — 2009
• Investigating the Roles of Follicular Dendritic Cells and Activation-induced Deaminase in Germinal CentersBryant Boulianne — 2013

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