DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

Keywords

Somatic hypermutation, Biology, DNA polymerase, Polymerase, Genetics

References

• Xeroderma pigmentosum variant response to etretinateМаракулина Ксения Александровна — 1990
• The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase ηChikahide Masutani, Rika Kusumoto, Ayumi Yamada — 1999
• The expanding polymerase universeMyron F. Goodman, Brigette L. Tippin — 2000
• Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis.Igor B. Rogozin, Н. А. Колчанов — 1992
• Somatic mutation hotspots correlate with DNA polymerase η error spectrumIgor B. Rogozin, Youri I. Pavlov, Katarzyna Bębenek — 2001
• Low fidelity DNA synthesis by human DNA polymerase-ηToshiro Matsuda, Katarzyna Bębenek, Chikahide Masutani — 2000
• Characteristics of sequences around individual nucleotide substitutions in IgVH genes suggest different GC and AT mutators.Jo Spencer, Mark Dunn, Deborah K. Dunn‐Walters — 1999
• Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells.Diana S. Smith, G Creadon, P. K. Jena — 1996
• poliota, a remarkably error-prone human DNA polymerase.Agnès Tissier, John P. McDonald, Ekaterina G. Frank — 2000
• Misinsertion and bypass of thymine–thymine dimers by human DNA polymerase ιAgnès Tissier, Ekaterina G. Frank, John P. McDonald — 2000
• Mechanisms of accurate translesion synthesis by human DNA polymerase ηChikahide Masutani, Rika Kusumoto, Shigenori Iwai — 2000
• DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation.Linda Bross, Yosho Fukita, Fraser McBlane — 2000
• Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.Amy Lehman, Susan Kirk‐Bell, C. F. Arlett — 1975
• Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.John P. Wittschieben, Mahmud K. K. Shivji, El–Nasir Lalani — 2000
• Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination.Simon Corbett, Ian M. Tomlinson, Erik L. L. Sonnhammer — 1997
• TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line.Julian E. Sale, Michael S. Neuberger — 1998
• Third complementarity‐determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non‐mutated genesKarli Rosner, David B. Winter, Robert E. Tarone — 2001
• Induction of somatic mutation in a human B cell line in vitro.Stéphane Denépoux, Diane Razanajaona, Dominique Blanchard — 1997
• Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J geneSerge Lebecque, Patricia J. Gearhart — 1990
• Clusters of point mutations are found exclusively around rearranged antibody variable genes.Patricia J. Gearhart, Daniel Bogenhagen — 1983

Cited by

• Cis and trans-acting elements in somatic hypermutationMaik Klasen — 2004
• Response 1 to 'Smaller role for pol η?'Igor B. Rogozin, Youri I. Pavlov, Thomas A. Kunkel — 2001
• Immunoglobulin Somatic Hypermutation: Double-Strand DNA Breaks, AID and Error-Prone DNA RepairXiaoping Wu, Junli Feng, Atsumasa Komori — 2003
• Cancer in xeroderma pigmentosum and related disorders of DNA repairPeter Benner, Ronda G. Hughes, Molly Sutphen — 2005
• Enhanced Activity of DNA Polymerase Iota in Mouse Brain Cells Is Associated with AggressivenessMaría Teresa Álvarez Moreno, Carmen Muñoz García — 2005
• DNA polymerase η is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturationAlexei Zhidkov, V. S. Marchenko, S. I. Yakovlenko — 2008
• Response 2 to 'Smaller role for pol η?'Patricia J. Gearhart, Xianmin Zeng — 2001
• DNA polymerases in immunity: profiting from errorsUrsula Storb — 2001
• Structural insights into DNA replication and lesion bypass by Y family DNA polymerasesKevin N. Kirouac — 2010
• Studies of Proliferating Cell Nuclear Antigen Mutant Proteins Defective in Translesion Synthesis and Mismatch RepairLynne M. Dieckman — 2013
• Xeroderma pigmentosum variant, XP-V: its product and biological roles.Chikahide Masutani, Fumio Hanaoka, Shamim Ahmad — 2008
• Smaller role for pol η?Thomas Dörner, Peter E. Lipsky — 2001
• The Structure and Replication of DNAA. Griffiths, Jeffrey H. Miller, D. Suzuki — 2000
• DNA replication to aid somatic hypermutation.Zhenming Xu, Hong Zan, Zsuzsanna Pál — 2007
• Inherited defects of immunoglobulin class switch recombination.Sven Kracker, Pauline Gardës, Anne Durandy — 2010
• Untersuchung der Regulation und Aktivität der DNA-Doppelstrangbruchreparatur in humanen B-LymphozytenMaren Mierau — 2005
• Analysis of the Function of DNA Polymerase Kappa and M17 in the Immune SystemDominik Schenten — 2003
• DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage.L. Jay Stallons — 2011
• Rôle des protéines AID et Bfl-1 dans les processus d'instabilité génomique et de survie cellulaire induits par l'oncoprotéine Tax au cours de la lymphomagénèse associée à l'infection par HTLV-1A. Riquet — 2014
• Local somatic hypermutation and class switch recombination in allergic rhinitis.Heather Coker — 2004

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• Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.Stella Martomo, Huseyin Saribasak, Masayuki Yokoi — 2008
• Requirement of the Activation-Induced Deaminase (AID) Gene for Immunoglobulin Gene ConversionHiroshi Arakawa, Jessica Hauschild, Jean-Marie Buerstedde — 2002
• Serological Analysis of the Deoxyribonucleic Acid Polymerase of Avian Oncornaviruses II. Comparison of Avian Deoxyribonucleic Acid PolymerasesRobert C. Nowinski, Kenneth F. Watson, A. Yaniv — 1972
• Characterization of a new murine cellular DNA polymerase.Dennis Livingston, L. E. Serxner, Donna J. Dormer Howk — 1974
• Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases alpha and beta.Kristin A. Eckert, Suzanne E. Hile — 1998
• 8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279.Holly Miller, Rajendra Prasad, Samuel H. Wilson — 2000
• Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutationJulian E. Sale, Daniella M. Calandrini, Minoru Takata — 2001
• Properties of DNA polymerases from young and ageing human fibroblasts.Vincent Murray — 1981