Modeling the Time Course of CD4 T-Lymphocyte Counts According to the Level of Virologic Rebound in HIV-1–Infected Patients on Highly Active Antiretroviral Therapy
Explore this paper's citation graph
Summary
After achieving an undetectable viral load on HAART, immunologic reconstitution is possible whatever the subsequent level of viral replication, except among patients with high-level rebound, meaning that delay in antiretroviral therapy switch can be possible in patients with low or intermediate rebound.
- Type
- article
- Published
- 2003-09-01
- Cited by
- 22
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W1963991773
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25988231
Keywords
Viral load, Medicine, Antiretroviral therapy, Immunology, Internal medicine
References
- CD4-cell count in HIV-1-infected individuals remaining viraemic with highly active antiretroviral therapy (HAART)
- The dynamics of CD4+ T-lymphocyte decline in HIV-infected individuals: a Markov modeling approach.
- Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremia
- Modeling Markers of Disease Progression by a Hidden Markov Process: Application to Characterizing CD4 Cell Decline
- Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease.
- The potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapy
- A review and synthesis of the HIV/AIDS epidemic as a multi-stage process.
- Use of immunological markers and continuous‐time Markov models to estimate progression of HIV infection in homosexual men
- Full suppression of viral load is needed to achieve an optimal CD4 cell count response among patients on triple drug antiretroviral therapy
- Markov modelling of changes in HIV‐specific cytotoxic T‐lymphocyte responses with time in untreated HIV‐1 infected patients
- Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease.
- Clinical Outcome of Patients with HIV-1 Infection according to Immunologic and Virologic Response after 6 Months of Highly Active Antiretroviral Therapy
- Comparison of the declines in CD4 counts in HIV-1-seropositive female sex workers and women from the general population in Nairobi, Kenya.
- Use of the Gibbs sampler to estimate transition rates between grades of coronary disease following cardiac transplantation.
- Resistance profile and cross‐resistance of HIV‐1 among patients failing a non‐nucleoside reverse transcriptase inhibitor‐containing regimen *
- Predictors of long-term increase in CD4(+) cell counts in human immunodeficiency virus-infected patients receiving a protease inhibitor-containing antiretroviral regimen.
- Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients : a prospective cohort study
- Survival improvement of AIDS-related progressive multifocal leukoencephalopathy in the era of protease inhibitors. Clinical Epidemiology Group. French Hospital Database on HIV.
- The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team.
- Markov chain Monte Carlo in Practice
Cited by
- Clinical audit: virological and immunological response to combination antiretroviral therapy in HIV patients at a Sydney sexual health clinic
- Avaliação da reconstituição do sistema imune em pacientes infectados pelo HIV-1 em uso de terapia anti-retroviral combinada
- Modèles semi-Markoviens : Application à l'analyse de l'évolution de pathologies chroniques
- Outcomes Following Virological Failure and Predictors of Switching to Second-line Antiretroviral Therapy in a South African Treatment Programme
- Markov Modelling of Immunological and Virological States in HIV‐1 Infected Patients
- Persistent low viral load on antiretroviral therapy is associated with T cell-mediated control of HIV replication
- Long‐term evolution of CD4 count in patients with a plasma HIV RNA persistently <500 copies/mL during treatment with antiretroviral drugs
- Current practices in laboratory monitoring of HIV infection
- Delaying a Treatment Switch in Antiretroviral-Treated HIV Type 1-Infected Patients with Detectable Drug-Resistant Viremia Does Not Have a Profound Effect on Immune Parameters: AIDS Clinical Trials Group Study A5115
- CD4+ T-Cell Recovery and Clinical Outcome in HIV-1-Infected Patients Exposed to Multiple Antiretroviral Regimens: Partial Control of Viremia Is Associated with Favorable Outcome
- Quantifying HIV for monitoring antiretroviral therapy in resource-poor settings.
- Markov modelling of HIV infection evolution in the HAART era
- Cumulative Viral Load and Virologic Decay Patterns after Antiretroviral Therapy in HIV-Infected Subjects Influence CD4 Recovery and AIDS
- Cervical neoplasia and highly active antiretroviral therapy.
- HIV viral load monitoring in resource-limited regions: optional or necessary?
- Multi-state models for defining degrees of chronicity related to HIV-infected patient therapy adherence.
- A Novel, Low-Cost Viral Load Diagnostic for HIV-1 and Assessing Barriers to Adoption of Technology in Tanzania
- A Multi-State Model Examining Patterns of Transitioning Among States of Engagement in Care in HIV-Positive Individuals Initiating Combination Antiretroviral Therapy
- Optimal Timing to Initiate Medical Treatment for a Disease Evolving as a Semi-Markov Process
- Effects of antiretroviral treatment and nadir CD4 count in progression to cardiovascular events and related comorbidities in a HIV Brazilian cohort: a multi-stage approach
Related papers
- The Sexual Behaviours of HIV Positive Patients Receiving Antiretroviral Therapy in HIV Treatment Centre in Nigeria
- Reverse Transcriptase Viral Load Correlates with RNA in SIV/SHIV-Infected Macaques
- HIV RNA level in early infection is predicted by viral load in the transmission source
- Raised viral load in patients with viral suppression on highly active antiretroviral therapy: transient increase or treatment failure?
- Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2.
- Estimation of the Predictive role of Plasma Viral load on CD4 decline in HIV-1-subtype C infected subjects in India
- Use of an improved quantitative polymerase chain reaction assay to determine differences in human rhinovirus viral loads in different populations
- Effect of hemodialysis and antiretroviral therapy on plasma viral load in HIV-1 infected hemodialysis patients.
- Predictive value of viral load measurements in asymptomatic untreated HIV‐1 infection: a mathematical model