Dynamic equilibrium between multiple active and inactive conformations explains regulation and oncogenic mutations in ErbB receptors.

Keywords

Receptor tyrosine kinase, ErbB, Extracellular, Intracellular, Biology

References

• Prediction and simulation of motion in pairs of transmembrane α-helicesAdzura Salam, Carsten Framme, Sebastián Wolf — 2007
• Characterization of an angiosarcoma-inducing mutation in the erbB oncogene.Harriet L. Robinson, Sharon Tracy, Nikitha Nair — 1992
• The intracellular tyrosine kinase domain of the epidermal growth factor receptor undergoes a conformational change upon autophosphorylation.Deborah L. Cadena, Chung‐leung Chan, Gordon N. Gill — 1994
• The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptors.Andrew Chantry — 1995
• Molecular characterization of three erbB transducing viruses generated during avian leukosis virus-induced erythroleukemia: extensive internal deletion near the kinase domain activates the fibrosarcoma- and hemangioma-inducing potentials of erbBM A Raines, Nita J. Maihle, C. Moscovici — 1988
• Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.Etta Livneh, Ron Prywes, O Kashles — 1986
• Reconstitution of the high affinity epidermal growth factor receptor on cell-free membranes after transmodulation by platelet-derived growth factor.Francesca Walker, Antony W. Burgess — 1991
• Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.H Kitayama, Yuzuru Kanakura, T Furitsu — 1995
• Oncogenic kinase signallingPeter Blume‐Jensen, Tony Hunter — 2001
• Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 geneOreste Segatto, C. Richter King, Jacalyn H. Pierce — 1988
• Structure of the Extracellular Region of HER3 Reveals an Interdomain TetherHyun‐Soo Cho, Daniel J. Leahy — 2002
• Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformationS. Massoglia, Andrew Gray, Thomas J. Dull — 1990
• Untangling the ErbB signalling networkYosef Yarden, Mark X. Sliwkowski — 2001
• Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.Thomas Garrett, Neil M. McKern, Meizhen Lou — 2002
• Structure of the membrane reconstituted transmembrane-juxtamembrane peptide EGFR(622-660) and its interaction with Ca2+/calmodulin.Takeshi Sato, Payal Pallavi, Urszula Golebiewska — 2006
• Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membraneTony Hunter, Nicholas Ling, Jonathan A. Cooper — 1984
• Protein-protein interactions in the allosteric regulation of protein kinases.Patricia Pellicena, John Kuriyan — 2006
• Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complexPhilip D. Jeffrey, Alicia A. Russo, Kornélia Polyák — 1995
• Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785).Carolyn Discafani, Marion L. Carroll, M. Brawner Floyd — 1999
• Hsp90 restrains ErbB‐2/HER2 signalling by limiting heterodimer formationAmi Citri, Judith Gan, Yaron Mosesson — 2004

Cited by

• Co-Conserved Features Associated with cis Regulation of ErbB Tyrosine KinasesAmar Mirza, Morad Mustafa, Eric Talevich — 2010
• Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapyGur Pines, Wolfgang J. Köstler, Yosef Yarden — 2010
• GxxxG motifs, phenylalanine, and cholesterol guide the self-association of transmembrane domains of ErbB2 receptors.Anupam Prakash, Lorant Janosi, Manolis Doxastakis — 2011
• Molecular dynamics of the asymmetric dimers of EGFR: simulations on the active and inactive conformations of the kinase domain.Napat Songtawee, David R. Bevan, Kiattawee Choowongkomon — 2015
• Molecular dynamics simulation reveals structural and thermodynamic features of kinase activation by cancer mutations within the epidermal growth factor receptorShunzhou Wan, Peter V. Coveney — 2011
• IGF2 Overexpression in Solitary Fibrous Tumors is Independent of Anatomic Location and is Related to Loss of ImprintingMihai Hajdu, Samuel Singer, Robert G. Maki — 2010
• Architecture and membrane interactions of the EGF receptorAnton Arkhipov, Yibing Shan, Rahul Das — 2013
• Sequence dependent lipid-mediated effects modulate the dimerization of ErbB2 and its associative mutants.Xavier Prasanna, P. J. Praveen, Durba Sengupta — 2013
• The ErbB Kinase Domain: Structural Perspectives into Kinase Activation and InhibitionRon Bose, Xuewu Zhang — 2008
• Protein logic: a statistical mechanical study of signal integration at the single-molecule level.Wiet de Ronde, Pieter Rein ten Wolde, Andrew Mugler — 2012
• Self-association of models of transmembrane domains of ErbB receptors in a lipid bilayer.Anupam Prakash, Lorant Janosi, Manolis Doxastakis — 2010
• Spatial structure of the transmembrane domain heterodimer of ErbB1 and ErbB2 receptor tyrosine kinases.Константин С. Минеев, Eduard V. Bocharov, Yulia Pustovalova — 2010
• Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmentNatalia Jura, Nicholas Endres, Kate Engel — 2009
• Physical-chemical principles underlying RTK activation, and their implications for human diseaseLijuan He, Kalina Hristova — 2011
• Structure of FGFR3 transmembrane domain dimer: implications for signaling and human pathologiesEduard V. Bocharov, Dmitry M. Lesovoy, Sergey A. Goncharuk — 2013
• Kinase‐mediated quasi‐dimers of EGFRErez M. Bublil, Gur Pines, Gargi Patel — 2010
• EGFR juxtamembrane domain, membranes, and calmodulin: kinetics of their interaction.Parijat Sengupta, Eran Bosis, Esther Nachliel — 2009
• Endogenous RhoG Is Rapidly Activated after Epidermal Growth Factor Stimulation through Multiple Guanine-Nucleotide Exchange FactorsThomas Samson, Christopher M. Welch, Elizabeth Monaghan-Benson — 2010
• Conformational dynamics of the EGFR kinase domain reveals structural features involved in activationAthanasios Papakyriakou, Dionisios Vourloumis, Fotini Tzortzatou‐Stathopoulou — 2009
• HER2 Transmembrane Domain Dimerization Coupled with Self-Association of Membrane-Embedded Cytoplasmic Juxtamembrane Regions.Pavel E. Bragin, Константин С. Минеев, Olga V. Bocharova — 2016

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