Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
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Summary
CSR is programmed to occur in a productive deletional orientation and does so via an unprecedented mechanism that involves in cis Igh organizational features in combination with frequent S-region DSBs initiated by AID, and is implicate ATM-dependent DSB-response factors in enforcing this mechanism.
- Type
- article
- Published
- 2015-08-26
- Cited by
- 117
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1960323088
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4468388
Keywords
Immunoglobulin class switching, Activation-induced (cytidine) deaminase, Cytidine deaminase, Biology, V(D)J recombination
References
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- Role for the BRCA1 C-terminal Repeats (BRCT) Protein 53BP1 in Maintaining Genomic Stability*
- Transcription-induced Cleavage of Immunoglobulin Switch Regions by Nucleotide Excision Repair Nucleases in Vitro*
- IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances
- Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions
- Multiplex Genome Engineering Using CRISPR/Cas Systems
Cited by
- A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets
- Molecular biology: Unequal opportunity during class switching
- Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes
- Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining
- Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells
- Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
- Open Peer Review
- AID hits the jackpot when missing the target
- Detecting DNA Double-Stranded Breaks in Mammalian Genomes by Linear Amplification-mediated High-Throughput Genome-wide Translocation Sequencing (LAM-HTGTS)
- CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation.
- A framework for philosophical biology
- Formation of Chromosomal Domains by Loop Extrusion
- The germinal center antibody response in health and disease
- A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination
- Highly sensitive and unbiased approach for elucidating antibody repertoires
- PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line
- Insulated neighborhoods: structural and functional units of mammalian gene control
- Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination.
- DNA Replication Origins in Immunoglobulin Switch Regions Regulate Class Switch Recombination in an R-Loop-Dependent Manner.
- Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency
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