Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.
Explore this paper's citation graph
Summary
It is reported that metabolic inhibitors such as cycloheximide (CHX) or actinomycin D (ActD) sensitize for CD95-induced apoptosis by strongly down-regulating FLIP and RIP expression.
- Type
- article
- Published
- 2000-07-15
- Cited by
- 234
- References
- 51
- OpenAlex
- https://openalex.org/W1957368412
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:936764
Keywords
FADD, Fas receptor, Apoptosis, Caspase 8, Death domain
References
- Pharmacological inhibition of programmed lymphocyte death.
- RIP mediates tumor necrosis factor receptor 1 activation of NF‐kappaB but not Fas/APO‐1‐initiated apoptosis.
- Modulation of caspase-8 and FLICE-inhibitory protein expression as a potential mechanism of Epstein-Barr virus tumorigenesis in Burkitt's lymphoma.
- An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9*
- Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.
- TCR engagement regulates differential responsiveness of human memory T cells to Fas (CD95)-mediated apoptosis.
- Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma.
- Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.
- Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.
- [Mitochondrial control of apoptosis].
- Two CD95 (APO‐1/Fas) signaling pathways
- The Role of c-FLIP in Modulation of CD95-induced Apoptosis*
- Monoclonal antibody-mediated tumor regression by induction of apoptosis.
- A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.
- Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
- Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.
- Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis.
- Flice-Inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to FAS-Mediated Apoptosis
- Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells*
- Resistance to Fas-mediated apoptosis: activation of Caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP
Cited by
- Radiation‐induced apoptosis in MOLT‐4 cells requires de novo protein synthesis independent of de novo RNA synthesis
- Cellular FLICE/Caspase-8–Inhibitory Protein as a Principal Regulator of Cell Death and Survival in Human Hepatocellular Carcinoma
- Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation.
- Signaling Active CD95 Receptor Molecules Trigger Co-translocation of Inactive CD95 Molecules into Lipid Rafts*
- Perturbations du contrôle traductionnel et troubles cognitifs dans un modèle expérimental de la maladie de Parkinson : études de neuroprotection
- RNA virus modulation of IFN, PI3K and apoptosis
- sFAS/sFASL and sMMP-7: New soluble markers of prognosis and response to therapy in advanced colorectal cancer
- To die or to differentiate: apoptotic and non-apoptotic roles of death molecules in Drosophila melanogaster
- Overview how adenocarcinoma cancer cells avoid immune- and chemotherapy-induced apoptosis.
- Etablierung von Testsystemen zur Charakterisierung der Apoptose-Induktion in Mumpsvirus-infizierten Zellen
- A new challenge for successful immunotherapy by tumors that are resistant to apoptosis: two complementary signals to overcome cross-resistance.
- Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria.
- Modulation of TRAIL signaling for cancer therapy.
- Uncovering the roles of intermediate filaments in apoptosis.
- Implication of TNF superfamily receptors and their functional antagonists in neuronal apoptotic cell death
- Oxygen deprivation induced cell death: An update
- Gangliosides expressed by the renal cell carcinoma cell line SK-RC-45 are involved in tumor-induced apoptosis of T cells.
- Regulation of cell death by c-FLIP phosphorylation.
- Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts
- Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL).
Related papers
- Cycloheximide-induced T-cell Death Is Mediated by a Fas-associated Death Domain-dependent Mechanism*
- RIP mediates tumor necrosis factor receptor 1 activation of NF‐kappaB but not Fas/APO‐1‐initiated apoptosis.
- c-FLIP Mediates Resistance of Hodgkin/Reed-Sternberg Cells to Death Receptor–induced Apoptosis
- Functional absence of FADD in PLC/PRF/5 hepatoma cells: possible involvement in the transformation to hepatoma in HBV-infected hepatocytes.
- FLIP protein and TRAIL-induced apoptosis.
- Polysaccharopeptide of Coriolus versicolor (PSP) induced apoptosis in HL-60 cells related to the upregulation of Fas
- Staphylococcus aureus Induces Apoptosis in Primary Bovine Mammary Epithelial Cells Through Fas-FADD Death Receptor-Linked Caspase-8 Signaling
- Role of antiapoptotic proteins in tumor necrosis factor-related apoptosis-inducing ligand and cisplatin-augmented apoptosis.
- Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells