Omega-3 PUFA docosahexaenoic acid decreases LPS-stimulated MUC5AC production by altering EGFR-related signaling in NCI-H292 cells.
Explore this paper's citation graph
Summary
Investigation of the influence of docosahexaenoic acid (DHA), one of the most important omega-3 PUFA contained in fish oil, on the production of MUC5AC in LPS-challenged human airway cells NCI--H292 indicates that DHA is capable of counteracting M UC5AC overproduction in L PS-stimulated cells by abrogating both EGFR phosphorylation and its downstream signaling pathway.
- Type
- article
- Published
- 2015-08-07
- Cited by
- 6
- References
- 28
- OpenAlex
- https://openalex.org/W1956990433
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24157501
Keywords
Docosahexaenoic acid, Cell biology, Fish oil, Chemistry, Epidermal growth factor receptor
References
- Pseudomonas Lipopolysaccharide Accelerates Wound Repair via Activation of a Novel Epithelial Cell Signaling Cascade1
- Chronic obstructive pulmonary disease exacerbations: latest evidence and clinical implications
- Proresolving Action of Docosahexaenoic Acid Monoglyceride in Lung Inflammatory Models Related to Cystic Fibrosis.
- Fish consumption may limit the damage of smoking on the lung.
- TOLL LIKE RECEPTORS IN DISEASES OF THE LUNG
- Helicobacter pylori Protein HP0175 Transactivates Epidermal Growth Factor Receptor through TLR4 in Gastric Epithelial Cells*
- Impact of the omega-3 to omega-6 polyunsaturated fatty acid ratio on cytokine release in human alveolar cells.
- LPS-stimulated MUC5AC production involves Rac1-dependent MMP-9 secretion and activation in NCI-H292 cells.
- Role of matrix metalloproteinase-9 in lipopolysaccharide-induced mucin production in human airway epithelial cells.
- Omega-3 fatty acid concentrate from Dunaliella salina possesses anti-inflammatory properties including blockade of NF-κB nuclear translocation.
- Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases.
- EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2.
- Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner*
- Epidermal growth factor system regulates mucin production in airways.
- The pathogenesis of chronic obstructive pulmonary disease.
- Effects of inducible nitric oxide synthase and xanthine oxidase inhibitors on SEB-induced interstitial pneumonia in mice
- Essential fatty acids in health and chronic disease.
- Mucin apoprotein expression in COPD.
- Docosahexaenoic acid and smoking-related chronic obstructive pulmonary disease. The Atherosclerosis Risk in Communities Study Investigators.
- Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria.
Cited by
- EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression
- Effect of polyunsaturated fatty acids (PUFAs) on airway epithelial cells' tight junction.
- NPS2143 Inhibits MUC5AC and Proinflammatory Mediators in Cigarette Smoke Extract (CSE)-Stimulated Human Airway Epithelial Cells
- Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction.
- The role of essential fatty acids in cystic fibrosis and normalizing effect of fenretinide
- Association between omega-3 polyunsaturated fatty acids and cataracts: results from a cross-sectional survey and mendelian randomization analysis
Related papers
- Low eicosapentaenoic acid fish oil is equivalent to single cell oil as a source of docosahexaenoic acid for infant formula
- Physiological Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA)—A Review
- Omega‐3 Fatty Acids (Fish Oil) Supplementation and Albuminuria: Not a Slam Dunk
- Characteristic presence of polyunsaturated fatty acids in marine psychrophilic vibrios
- Recent advances in functional analysis of polyunsaturated fatty acid synthases.
- New Zealand women have suboptimal intakes of long chain omega-3 polyunsaturated fatty acids during pregnancy-a cross sectional study.
- Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better.
- Confusion over different types of n-3 polyunsaturated fatty acids
- The Supplementation of Docosahexaenoic Acid-Concentrated Fish Oil Enhances Cognitive Function in Puppies