Association of cyclin-bound p34cdc2 with subcellular structures in xenopus eggs.
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Summary
It is shown that in Xenopus eggs stimulated to enter the early embryonic cell cycle by an electric shock, part of the p34cdc2 becomes associated with subcellular fractions as the eggs progress towards mitosis, and it seems that cyclin subunits target p34c2 to specific cellular sites and this is certainly important for its function.
- Type
- article
- Published
- 1992-06-01
- Cited by
- 19
- References
- 67
- OpenAlex
- https://openalex.org/W1951886496
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35183511
Keywords
Biology, Cyclin, Cell biology, Cyclin A, Cyclin B
References
- Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
- The A‐ and B‐type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.
- Cyclin is a component of the sea urchin egg M‐phase specific histone H1 kinase.
- Protein phosphatases come of age.
- A post‐ribosomal supernatant from activated Xenopus eggs that displays post‐translationally regulated oscillation of its cdc2+ mitotic kinase activity.
- The mitotic apparatus-associated 51-kDa protein from sea urchin eggs is a GTP-binding protein and is immunologically related to yeast polypeptide elongation factor 1 alpha.
- Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.
- Cyclin A is required at two points in the human cell cycle.
- Regulation of protein synthesis in mammalian cells. II. Inhibition of protein synthesis at the level of initiation during mitosis.
- High resolution two-dimensional electrophoresis of proteins.
- MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.
- Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.
- The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.
- Increased phosphorylation of elongation factor 2 during mitosis in transformed human amnion cells correlates with a decreased rate of protein synthesis.
- The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization.
- The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system.
- Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis.
- The cell cycle dependence of protein synthesis during Xenopus laevis development.
- Evidence for simultaneous derepression of messenger RNA and the guanine nucleotide exchange factor in fertilized sea urchin eggs.
- Cyclin is degraded by the ubiquitin pathway
Cited by
- Inhibition of RNA polymerase III transcription by a ribosome-associated kinase activity.
- In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2.
- Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.
- Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts.
- Mitotic regulation of protein phosphatases by the fission yeast sds22 protein.
- A Xenopus maternal effect mutant gene affects oocyte meiotic reinitiation and fertilization.
- Tyrosine-Phosphorylated Extracellular Signal–Regulated Kinase Associates with the Golgi Complex during G2/M Phase of the Cell Cycle
- Morphological Analysis of CDC2 and Glycogen Synthase Kinase 3β Phosphorylation as Markers of G2 → M Transition in Glioma
- p63cdc13, a B-type cyclin, is associated with both the nucleolar and chromatin domains of the fission yeast nucleus.
- Centrosome assembly in vitro: role of gamma-tubulin recruitment in Xenopus sperm aster formation
- A method that allows the assembly of kinetochore components onto chromosomes condensed in clarified Xenopus egg extracts.
- Characterization of a MAPKK-like protein kinase TOPK.
- Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.
- Differential regulation of cyclin B1 RNA and protein expression during hepatocyte growth in vivo.
- Members of the NAP/SET family of proteins interact specifically with B- type cyclins
- Dynamic Recruitment of Cdc2 to Specific Microtubule Structures during Mitosis
- Pre-M phase-promoting factor associates with annulate lamellae in Xenopus oocytes and egg extracts.
- Dissection of the Cell Cycle Using Cell-Free Extracts From Xenopus Laevis
- 1 Pre-MPF associates with annulate lamellae in Xenopus oocytes and egg extracts
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