Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme.
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Summary
A novel link between transcription factor regulation, oxidative signalling and DNA repair processes in higher eukaryotes is suggested and Ref‐1 is the major AP‐1 redox activity in Hela nuclear extracts.
- Type
- article
- Published
- 1992-09-01
- Cited by
- 909
- References
- 2
- Access
- Open access
- OpenAlex
- https://openalex.org/W1949973946
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24218278
Keywords
Curran, Biology, Library science, Computer science
References
Cited by
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- Transcription factors AP-1 and NF-κB: Where steroids meet the gold standard of anti-rheumatic drugs
- Modulation of p53 protein conformation and DNA‐binding activity by intracellular chelation of zinc
- Activation of the JAK-STAT pathway by reactive oxygen species.
- Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters.
- Reconstitution of Proliferating Cell Nuclear Antigen-dependent Repair of Apurinic/Apyrimidinic Sites with Purified Human Proteins*
- Redox factor‐1/APE suppresses oxidative stress by inhibiting activity of the rac1 GTPase
- Exploring the Early Effects of AP Endonuclease 1 Knockdown in Zebrafish Embryogenesis
- Effect of Glutathione on Lung Activator Protein-1 Activation and Heme Oxygenase-1 Induction in the Immature Rat
- Attenuated transcriptional responses to oxidative stress in the aged rat brain
- Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation.
- Immunohistochemical determination of thioredoxin and glutaredoxin distribution in the human cervix ,and possible relation to cervical ripening
- Role of the HAP1 protein in repair of oxidative DNA damage and regulation of transcription factors.
- Thioredoxin reductase as a novel molecular target for cancer therapy.
- APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival
- Oxidative stress and superoxide dismutase in development, aging and gene regulation
- Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair
- Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy.
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