Oligomerization of oncoprotein p53
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Summary
Detailed analysis of the quaternary structure of p53 indicated that an appropriate modification of at least one of the two proteins appears to be necessary for complex formation, and Pulse-labeling experiments revealed that oligomerization of p 53 is a very rapid process.
- Type
- article
- Published
- 1988-12-01
- Cited by
- 150
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W1944714834
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42842986
Keywords
Biology, Phosphoprotein, Intracellular, Antigen, Cell culture
References
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- Energy requirement for degradation of tumor-associated protein p53
- Immunologically distinct p53 molecules generated by alternative splicing
- Overproduction of protein p53 contributes to simian virus 40-mediated transformation
- Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells
- Complex formation of simian virus 40 large T antigen with cellular protein p53
- Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
- Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens
- Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP
- Antigenic binding sites of monoclonal antibodies specific for simian virus 40 large T antigen
- Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53
- Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines
- Pre-crisis mouse cells show strain-specific covariation in the amount of 54-kilodalton phosphoprotein and in susceptibility to transformation by simian virus 40.
- Transformation associated p53 protein is encoded by a gene on human chromosome 17
- Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53
- Specific interaction between the p53 cellular tumour antigen and major heat shock proteins
- Mouse p53 inhibits SV40 origin-dependent DNA replication
- Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
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- Tumor suppressor genes.
- Lymphocyte death, p53, and the problem of the "undead" cell.
- Genetics of colorectal cancer.
- Neurotoxicological effects of nicotine on the embryonic development of cerebellar cortex of chick embryo during various stages of incubation.
- p53: DNA damage, DNA repair, and apoptosis.
- Identificação e Caracterização de Pacientes em Risco para Câncer de Mama Hereditário no Sul do Brasil
- Role of p53 in apoptosis.
- The quaternary structures of SV40 large T antigen and tumor suppressor p53: analysis by gel electrophoresis.
- Involvement of p53 in the S-phase Checkpoint during Nucleotide Deficiencies
- Molecular phenotyping of head and neck cancer.
- Régulation de l’apoptose dépendante de p53 par le FGF1 intracellulaire : caractérisation des mécanismes d’action
- Apoptosis in Immunology
- Molecular response prediction in multimodality treatment for adenocarcinoma of the esophagus and esophagogastric junction.
- Tumor suppressor p53 and transcriptional changes in cellular stress responses to UV radiation
- p53 mutations in nonastrocytic human brain tumors.
- Evidence for the involvement of a potential second tumor suppressor gene on chromosome 17 distinct from p53 in malignant astrocytomas.
- Tumor suppressor genes and human cancer.
- Function of the anterior gradient protein family in cancer
- Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutations
- Expresión de oncogenes, receptores hormonales esteroideos y marcadores de proliferación en el carcinoma endometrial
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