Seeing the forest and trees: whole‐body and whole‐brain imaging for circadian biology
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Summary
Current methods and strategy for making organs translucent and possible applications to circadian biology, including the coupling of circadian rhythms among different brain regions, brain activity in sleep–wake cycles and the role of migrating cells such as immune cells and cancer cells in chronopharmacology are summarized.
- Type
- review
- Published
- 2015-09-01
- Cited by
- 7
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W1943753802
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44920823
Keywords
Circadian rhythm, Biology, Circadian clock, Neuroscience, Computational biology
References
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- Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms
- Disorganization of the rat activity rhythm by chronic treatment with methamphetamine.
- Food‐anticipatory circadian rhythms: concepts and methods
- Visualizing whole-brain activity and development at the single-cell level using light-sheet microscopy.
- Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions.
- Measurement of internal body time by blood metabolomics
- Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms.
- Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
- A High-Throughput Assay for siRNA-Based Circadian Screens in Human U2OS Cells
- Neuroanatomy of the Extended Circadian Rhythm System
- Advanced CLARITY for rapid and high-resolution imaging of intact tissues
- Three-dimensional imaging of solvent-cleared organs using 3DISCO
Cited by
- Whole-body and Whole-Organ Clearing and Imaging Techniques with Single-Cell Resolution: Toward Organism-Level Systems Biology in Mammals.
- Chemical Principles in Tissue Clearing and Staining Protocols for Whole-Body Cell Profiling.
- Rigid Cooperation of Per1 and Per2 proteins
- Bottleneck towards the Practice of Multi-/ Interdisciplinary Nature of Systems Pharmacology and Systems Medicine: Experience from India
- A Whole Brain Staining, Embedding, and Clearing Pipeline for Adult Zebrafish to Visualize Cell Proliferation and Morphology in 3-Dimensions
- A new approach for immunostaining nervous systems in isolated organs and whole animals
- High-speed mapping of whole-mouse peripheral nerves at subcellular resolution
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