PTN Signaling: Components and Mechanistic Insights in Human Ovarian Cancer
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Summary
It is shown that pleiotrophin (PTN) is expressed, produced, and secreted in a panel of EOC cell lines, providing the first experimental evidence that PTN and its signaling components may be of significance in the pathogenesis of epithelial ovarian cancer.
- Type
- article
- Published
- 2014-11-21
- Cited by
- 27
- References
- 76
- Access
- Open access
- OpenAlex
- https://openalex.org/W1938298163
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25160951
Keywords
Biology, Gene knockdown, Ovarian cancer, Cancer research, Gene silencing
References
- Characterization of the Activation of Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) by Hypoxia Inducible Factor-2 Alpha
- Implication of Inflammatory Macrophages, Nuclear Receptors, and Interferon Regulatory Factors in Increased Virulence of Pandemic 2009 H1N1 Influenza A Virus after Host Adaptation
- Aumento della captazione del radioiodio indotto da selumetinib in pazienti con cancro della tiroide
- Expression and Function of the Receptor Protein Tyrosine Phosphatase ζ and Its Ligand Pleiotrophin in Human Astrocytomas
- Development of human tumor cell line panels for use in disease-oriented drug screening.
- A receptor-type protein tyrosine phosphatase PTP zeta is expressed in human cutaneous melanomas.
- Enhanced antitumorigenic effects in glioblastoma on double targeting of pleiotrophin and its receptor ALK.
- Significance of the expression of the growth factor pleiotrophin in pancreatic cancer patients.
- Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3).
- The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.
- Pleiotrophin can be rate-limiting for pancreatic cancer cell growth.
- Pleiotrophin Enhances Clonal Growth and Long‐Term Expansion of Human Embryonic Stem Cells
- Effect of Extracellular Signal-regulated Kinase on p53 Accumulation in Response to Cisplatin*
- Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta.
- Anti-proliferative effect in epithelial ovarian cancer cells by MEK Inhibitor AZD6244
- Reproductive risk factors for epithelial ovarian cancer according to histologic type and invasiveness.
- Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells
- Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin.
- A Cross-Platform Comparison of Affymetrix and Agilent Microarrays Reveals Discordant miRNA Expression in Lung Tumors of c-Raf Transgenic Mice
- Network-based analysis of calcium-binding protein genes identifies Grp94 as a target in human oral carcinogenesis
Cited by
- High expression of CTHRC1 promotes EMT of epithelial ovarian cancer (EOC) and is associated with poor prognosis
- Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer
- Pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta as regulators of angiogenesis and cancer.
- Correlation of Collagen Triple Helix Repeat Containing 1 Overexpression With Lymph Node and Peritoneal Metastasis in Epithelial Ovarian Cancer
- Therapeutic silence of pleiotrophin by targeted delivery of siRNA and its effect on the inhibition of tumor growth and metastasis
- Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells
- MOLECULAR CHARACTERIZATION OF THE ONCOGENIC POTENTIAL AND MECHANISMS OF CYTOMEGALOVIRUS INFECTING MRC-5 CELLS
- Midkine and Pleiotrophin Concentrations in Needle Biopsies of Breast and Lung Masses
- Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.
- Hmgb3 Induces the Differentiation of Uterine Stromal Cells Through Targeting Ptn
- Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma
- The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression
- The Expression, Functions, Interactions and Prognostic Values of PTPRZ1: A Review and Bioinformatic Analysis
- Assessing the Angiogenic Efficacy of Pleiotrophin Released from Injectable Heparin-Alginate Gels
- Improved Synthesis of First Cell-Permeable Allosteric PTPRZ Inhibitor NAZ2329
- Single‐cell RNA sequencing of the Mongolia sheep testis reveals a conserved and divergent transcriptome landscape of mammalian spermatogenesis
- Effects of Pleiotrophin (PTN) on the resistance to paclitaxel in ovarian cancer cells
- Protein Tyrosine Phosphatase Receptor Zeta 1 as a Potential Target in Cancer Therapy and Diagnosis
- Single-cell analysis reveals specific neuronal transition during mouse corticogenesis
- PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC
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