Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1)

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Summary

The location and nature of the nuclear localization signal of PB1 is examined by using deletion mutants and chimeric constructions with chicken muscle pyruvate kinase, a cytoplasmic protein, to show that the function of both regions is required for nuclear localization and that one region alone is not sufficient.

Type
article
Published
1990-08-01
Cited by
145
References
46
Access
Open access

Keywords

Nuclear localization sequence, Biology, NLS, Nuclear export signal, Nuclear protein

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