Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1)
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Summary
The location and nature of the nuclear localization signal of PB1 is examined by using deletion mutants and chimeric constructions with chicken muscle pyruvate kinase, a cytoplasmic protein, to show that the function of both regions is required for nuclear localization and that one region alone is not sufficient.
- Type
- article
- Published
- 1990-08-01
- Cited by
- 145
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1931572731
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25986539
Keywords
Nuclear localization sequence, Biology, NLS, Nuclear export signal, Nuclear protein
References
- The effect of protein context on nuclear location signal function.
- The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen
- The structure of cat muscle pyruvate kinase.
- Identification of the sequence responsible for the nuclear accumulation of the influenza virus nucleoprotein in Xenopus oocytes.
- A domain of SV40 capsid polypeptide VP1 that specifies migration into the cell nucleus.
- Homologous interference mediated by defective interfering influenza virus derived from a temperature-sensitive mutant of influenza virus
- Mutations in the nuclear lamin proteins resulting in their aberrant assembly in the cytoplasm.
- Identification of domains involved in nuclear uptake and histone binding of protein N1 of Xenopus laevis.
- Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor.
- Nucleoplasmin cDNA sequence reveals polyglutamic acid tracts and a cluster of sequences homologous to putative nuclear localization signals.
- The nuclear migration signal of Xenopus laevis nucleoplasmin.
- Two nuclear location signals in the influenza virus NS1 nonstructural protein
- The intranuclear location of simian virus 40 polypeptides VP2 and VP3 depends on a specific amino acid sequence
- Pentapeptide nuclear localization signal in adenovirus E1a
- Sequence analysis of the polymerase 1 gene and the secondary structure prediction of polymerase 1 protein of human influenza virus A/WSN/33
- Nuclear localization of the adenovirus DNA-binding protein: requirement for two signals and complementation during viral infection
- Intracellular localization of the viral polymerase proteins in cells infected with influenza virus and cells expressing PB1 protein from cloned cDNA
- Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes
- Homeo domain of the yeast repressor alpha 2 is a sequence-specific DNA-binding domain but is not sufficient for repression.
- Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
Cited by
- Threonine 157 of Influenza Virus PA Polymerase Subunit Modulates RNA Replication in Infectious Viruses
- Expression, nuclear transport, and phosphorylation of adenovirus DNA replication proteins.
- Regulated gene expression after retroviral vector-mediated delivery of cancer-relevant therapeutic genes.
- Etudes structurales et fonctionnelles de la nucléoprotéine et de la polymérase du virus de la grippe en association avec leur transporteur nucléaire humain
- Molecular Epidemiology and Evolution of Influenza A(H1N1) pdm09 Virus in Kenya
- Immuno-regulatory dynamics of non-structural protein 1 of avian influenza A viruses
- Etudes structurales et fonctionnelles des protéines virales impliquées dans le trafic intracellulaire du génome du virus de la grippe
- Molecular Recognition in Host-Parasite Interactions
- An Unconventional NLS is Critical for the Nuclear Import of the Influenza A Virus Nucleoprotein and Ribonucleoprotein
- Novel catalytic activity associated with positive-strand RNA virus infection: nucleic acid-stimulated ATPase activity of the plum pox potyvirus helicaselike protein
- Influenza A viruses and PI3K signalling
- Intracellular localization of the Apn1 DNA repair enzyme of Saccharomyces cerevisiae. Nuclear transport signals and biological role.
- Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors.
- Characterization of Influenza Virus PB1 Protein Binding to Viral RNA: Two Separate Regions of the Protein Contribute to the Interaction Domain
- Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex
- The influenza virus RNA synthesis machine
- Distal protein sequences can affect the function of a nuclear localization signal.
- The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain
- Early host response and immune signaling to 2009 pandemic influenza A (H1N1) viruses in primary cell culture models.
- Conservational Analysis of Influenza A Virus RNA-dependent RNA Polymerase
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