Increased AβPP Processing in Familial Danish Dementia Patients

Keywords

Danish, Dementia, Mutation, Amyloid precursor protein, Biology

References

• Generation of an Apoptotic Intracellular Peptide by γ-Secretase Cleavage of Alzheimer's Amyloid ß Protein PrecursorBrent J. Passer, Luca Pellegrini, Claudio Russo — 2000
• Familial Danish Dementia: A Novel Form of Cerebral Amyloidosis Associated with Deposition of Both Amyloid‐Dan and Amyloid‐BetaJanice L. Holton, Tammaryn Lashley, Jorge Ghiso — 2002
• When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40Michael S. Wolfe — 2007
• The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.Shuji Matsuda, Luca Giliberto, Yukiko Matsuda — 2005
• Molecular biology and genetics of Alzheimer's disease.Peter St George‐Hyslop, Agnès Petit-Paitel — 2005
• A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.Xinwei Cao, Thomas C. Südhof — 2001
• Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's diseaseJanaky Coomaraswamy, Ellen Kilger, Heidrun Wölfing — 2010
• Generation and Initial Characterization of FDD Knock In MiceLuca Giliberto, Shuji Matsuda, Rubén Vidal — 2009
• Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analysesLars Bertram, Rudolph E. Tanzi — 2008
• Molecular biology and genetics of Alzheimer's diseaseAdriano Jiménez‐Escrig, C. Bianco‐Jerez, L. Orensanz — 1995
• Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.Bart De Strooper — 2003
• Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesiclesShuji Matsuda, Yukiko Matsuda, Erik L. Snapp — 2009
• Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brainHaruhiko Akiyama, Hiromi Kondo, Tetsuaki Arai — 2003
• N-APP binds DR6 to cause axon pruning and neuron death via distinct caspasesA. Nikolaev, Todd McLaughlin, D. O’Leary — 2009
• Memory deficits due to Familial British Dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosisRobert Tamayev, Luca Giliberto, Wei Li — 2010
• BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.Angeliki Fotinopoulou, Maria Tsachaki, Maria Vlavaki — 2005
• Cerebral Amyloid Angiopathy and Parenchymal Amyloid Deposition in Transgenic Mice Expressing the Danish Mutant Form of Human BRI2Rubén Vidal, Ana G. Barbeito, Leticia Miravalle — 2008
• Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficitsRobert Tamayev, Shuji Matsuda, Mauro Fà — 2010
• Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription.Meir H. Scheinfeld, Enrico Ghersi, Karen Laky — 2002
• BRI2 Inhibits Amyloid β-Peptide Precursor Protein Processing by Interfering with the Docking of Secretases to the SubstrateShuji Matsuda, Luca Giliberto, Yukiko Matsuda — 2008

Cited by

• An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss博 江橋, 洋子 西嶋, 秀太郎 芝山 — 2013
• Molecular mechanisms of amyloid self-regulationM. Landreh — 2012
• Role of BRI2 in DementiaMarta del Campo, Charlotte E. Teunissen — 2014
• Lessons from a Rare Familial Dementia: Amyloid and BeyondAdam Cantlon, Carlo Sala Frigerio, Dominic M. Walsh — 2015
• Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memoryFabrizio Biundo, Keita Ishiwari, Dolores Del Prete — 2015
• Memory deficits of British Dementia knock-in mice are prevented by APP haploinsufficiencyRobert Tamayev, Luciano D'adamio — 2012
• BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cellsM. Del Campo, Catarina R. Oliveira, Wiep Scheper — 2015
• BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease.Marta Del Campo, Jeroen J.M. Hoozemans, Lois-Lee Dekkers — 2014
• Proteomic Characterization of a Mouse Model of Familial Danish DementiaMonica Vitale, Giovanni Renzone, Shuji Matsuda — 2012
• Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease.M. Del Campo, Anita Stargardt, Robert Veerhuis — 2015
• The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseasesBeverly W. Baron, Rebecca M. Baron, Joseph M. Baron — 2014
• Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protectionRobert Tamayev, Nsikan Akpan, Ottavio Arancio — 2012
• Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementiaRobert Tamayev, Luciano D'adamio — 2012
• BRI2 Interacts with BACE1 and Regulates Its Cellular Levels by Promoting its Degradation and Reducing Its mRNA LevelsMaria Tsachaki, Angeliki Fotinopoulou, Nefeli Slavi — 2013
• β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementiaRobert Tamayev, Shuji Matsuda, Ottavio Arancio — 2012
• The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers*Adam Cantlon, Carlo Sala Frigerio, Darragh B. Freir — 2015
• Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaFabrizio Biundo, Keita Ishiwari, Dolores Del Prete — 2016
• Identification of interacting protein partners of TOPORS in the retinaB. Czub, Amna Z Shah, G. Alfano — 2013
• A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis *Robert J. Andrew, Katherine A. B. Kellett, Gopal Thinakaran — 2016
• BRICHOS interactions with amyloid proteins and implications for Alzheimer diseaseLisa Dolfe — 2016

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