Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer?
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Summary
This review summarizes existing knowledge of the expression and function of the EP receptor subtypes in human and rodent intestine during tumorigenic progression and describes the current literature on targeting EP receptor signaling during intestinal tumorigenesis.
- Type
- article
- Published
- 2004-08-01
- Cited by
- 186
- References
- 94
- Access
- Open access
- OpenAlex
- https://openalex.org/W1918606482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6300106
Keywords
Colorectal cancer, Receptor, Cancer research, Carcinogenesis, Cancer
References
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- Distribution of prostaglandin E receptors in the rat gastrointestinal tract.
- Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo.
- Indomethacin accelerates clearance of labeled cells and increases DNA synthesis in gastrointestinal mucosa of the rat
- Cellular distribution of prostanoid EP receptors mRNA in the rat gastrointestinal tract.
Cited by
- Amyloid β peptide (25–35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes
- Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism.
- G-protein-coupled receptors and cancer
- Involvement of eicosanoid signalling in epithelial cell migration
- Eicosanoid Regulation of Hematopoietic Stem and Progenitor Cell Function
- The Role of Prostaglandin E2/EP4 Prostanoid Receptor Signaling in Colorectal Carcinogenesis
- COX-2 induces lytic reactivation of EBV through PGE2 by modulating the EP receptor signalling Pathway
- Randomised controlled trial of the effects of fish oil emulsion in total parenteral nutrition upon tumour vascularity in patients with hepatic colorectal metastases
- Pharmacological modulation and manipulation of cancer drug resistance
- A systematic genome-wide association analysis for inflammatory bowel diseases (IBD)
- Investigations of bioactivity, disposition, and metabolism of lipids through liquid chromatography-mass spectrometry
- Androgens and the masculinisation programming window
- Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model
- Pulse exposure of haematopoietic grafts to prostaglandin E2 in vitro facilitates engraftment and recovery
- The effect of eicosapentaenoic acid on biomarkers of growth and vascularity of human colorectal cancer liver metastases
- Cyclooxygenases in hepatocellular carcinoma.
- Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells.
- ROLE OF PROSTAGLANDIN E2 IN THE REGULATION OF PANCREATIC STELLATE CELLS HYPER ACTIVITY ASSOCIATED WITH PANCREATIC CANCER
- Prostaglandin E2 Receptors and COX Enzymes in Human Hepatocellular Carcinoma
- Silymarin suppresses the PGE2‐induced cell migration through inhibition of EP2 activation; G protein‐dependent PKA‐CREB and G protein‐independent Src‐STAT3 signal pathways
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- 2001 Enhancement of action potential by transient Ca2+ current in the newt olfactory receptor cell
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