Identification and characterization of NleA, a non‐LEE‐encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7
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Summary
A novel protein, NleA, encoded in a prophage‐associated pathogenicity island within the EHEC genome, distinct from the LEE was determined to play a key role in virulence of C. rodentium in a mouse infection model.
- Type
- article
- Published
- 2004-03-01
- Cited by
- 233
- References
- 61
- OpenAlex
- https://openalex.org/W1913315326
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43296852
Keywords
Biology, Effector, Pathogenicity island, Virulence, Type three secretion system
References
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- Targeting of proteins to the Golgi apparatus
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- Targeting of an enteropathogenic Escherichia coli (EPEC) effector protein to host mitochondria
- Enteropathogenic Escherichia coli induces modification of the focal adhesions of infected host cells
- Characterization of translocation pores inserted into plasma membranes by type III‐secreted Esp proteins of enteropathogenic Escherichia coli
Cited by
- Enterohemorrhagic Escherichia coli effector EspL2 induces actin microfilament aggregation through annexin 2 activation
- Functional domains and motifs of bacterial type III effector proteins and their roles in infection.
- Genetic Background and Mobility of Variants of the Gene nleA in Attaching and Effacing Escherichia coli
- Facteurs de virulence et dissémination dans l'environnement via les effluents d'abattoirs d'animaux de boucherie d'Escherichia coli entérohémorragiques (EHEC)
- Studies on gene expression in a pathogenic bacterium
- The Epinephrine/Norepinephrine/Autoinducer-3 Interkingdom Signaling System in Escherichia coli O157:H7.
- The Influence of the Bovine Fecal Microbiota on the Shedding of Shiga Toxin-Producing Escherichia coli (STEC) by Beef Cattle
- Computational characterization of prokaryotic genomic islands
- Regulation of type III secretion in enterohaemorrhagic Escherichia coli
- Regulation of glucosamine-6-phosphate synthase synthesis by a hierarchical acting cascade composed of two small regulatory RNAs in Escherichia coli .
- A New Murine Model For Enterohemorrhagic Escherichia coli Infection Reveals That Actin Pedestal Formation Facilitates Mucosal Colonization and Lethal Disease: A Dissertation
- Interaction d'Escherichia coli entérohémorragique (EHEC) avec Acanthamoeba castellanii et rôle du régulon Pho chez les EHEC
- Rôle de Paa dans la pathogénicité des Escherichia coli attachants et effaçants (AEEC)
- EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function
- Development, characterization and transcriptional profiling of a mouse model of fatal infectious diarrhea and colitis
- Escherichia coli O157:H7 colonization in small domestic ruminants.
- Colonization of cattle by non-O157 Shiga Toxin-producingEscherichia coli serotypes
- Sec24 interaction is essential for localization and virulence‐associated function of the bacterial effector protein NleA
- CesT is a multi‐effector chaperone and recruitment factor required for the efficient type III secretion of both LEE‐ and non‐LEE‐encoded effectors of enteropathogenic Escherichia coli
- Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation
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