Zinc or Copper Deficiency-Induced Impaired Inflammatory Response to Brain Trauma May Be Caused by the Concomitant Metallothionein Changes
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Summary
Results obtained in mice with a null mutation for the MT-I + II isoforms strongly suggest that most of the effects observed in the rat brain after zinc and copper deficiencies are attributable to the concomitant changes in the MT expression.
- Type
- article
- Published
- 2001-04-01
- Cited by
- 59
- References
- 460
- OpenAlex
- https://openalex.org/W1909512474
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26052845
Keywords
Metallothionein, Concomitant, Inflammatory response, Copper deficiency, Zinc
References
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- Neurochemical sequelae of traumatic brain injury: therapeutic implications.
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- Implications and inferences of metallothionein structure.
- Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines.
- Metallothionein in blood, bile and urine.
- Zinc-binding proteins in the brain.
- Metallothionein and zinc metabolism in endotoxin shock rats.
Cited by
- The "metal transcription factor" MTF-1: biological facts and medical implications.
- Metallothionein‐I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte‐targeted interleukin‐6 expression
- Red mold rice promoted antioxidase activity against oxidative injury and improved the memory ability of zinc-deficient rats.
- Effect of exercise on Special Aviation Gymnastics Instruments on blood serum levels of selected biochemical indices in cadets.
- Gene Expression Profile Changes Are Commonly Modulated across Models and Species after Traumatic Brain Injury
- Metallothionein expression and oxidative stress in the brain.
- Characterisation of the transcriptomic and proteomic profile of astrocytes in multiple sclerosis
- Metallothioneins are multipurpose neuroprotectants during brain pathology
- Role of metallothionein-III following central nervous system damage.
- Zinc supplementation provides behavioral resiliency in a rat model of traumatic brain injury
- Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation)
- Zinc deficiency and oxidative stress in brain: magnetic resonance investigations in weanling rats
- Metallothioneins and brain injury: What transgenic mice tell us
- Analysis of the Cerebral Transcriptome in Mice Subjected to Traumatic Brain Injury: Importance of IL-6
- Altered Central Nervous System Cytokine-Growth Factor Expression Profiles and Angiogenesis in Metallothionein-I+II Deficient Mice
- METALLOTHIONEIN EXPRESSION AND ROLES IN THE CENTRAL NERVOUS SYSTEM
- The Stoichiometric Transition from Zn6Cu1-Metallothionein to Zn7-Metallothionein Underlies the Up-regulation of Metallothionein (MT) Expression
- Lack of NF-κB p50 Exacerbates Degeneration of Hippocampal Neurons after Chemical Exposure and Impairs Learning
- Astrocyte-targeted expression of interleukin-3 and interferon-alpha causes region-specific changes in metallothionein expression in the brain.
- Metallothionein I and II mitigate age‐dependent secondary brain injury
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