A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes.
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Summary
The observation that a marked MT-I gene, as well as heterologous genes, when placed in the context of 17 kb of flanking sequence from the MT locus, are inducible by DEX and lipopolysaccharide in transgenic mice renewed the search for the GRE.
- Type
- article
- Published
- 1997-09-16
- Cited by
- 125
- References
- 45
- OpenAlex
- https://openalex.org/W9294160
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24650605
Keywords
Political science
References
- Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
- Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis.
- Metallothionein III : biological roles and medical implications
- Glucocorticoid regulation of the mouse metallothionein I gene is selectively lost following amplification of the gene.
- Endotoxin induction of murine metallothionein gene expression.
- Regulation of alpha-tropomyosin and N5 genes by a shared enhancer. Modular structure and hierarchical organization.
- Glucocorticoid regulation of metallothionein-I mRNA synthesis in cultured mouse cells.
- Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.
- Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles
- Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice.
- A new technique for the assay of infectivity of human adenovirus 5 DNA.
- Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.
- Germ-line transformation of mice.
- Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene
- Glucocorticoid regulation of human growth hormone expression in transgenic mice and transiently transfected cells.
- Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids
- Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.
- In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone
- Cloning and characterization of the 5'-flanking region of metallothionein-I gene from Chinese hamster ovary cells.
- An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.
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- Transcriptome Profiling and Genetic Analysis to Identify Susceptibility Genes for Crohn’s Disease
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- Delay of M‐phase onset by aphidicolin can retain the nuclear localization of zinc and metallothionein in 3T3‐L1 fibroblasts
- Identification of two metallothionein isoforms by molecular cloning of their cDNAs in fresh-water fish, crucian carp (Carassius-cuvieri)
- Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome.
- The possible separation of 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation and hyperplasia by Compound A
- Regulation of Intracellular Copper by Induction of Endogenous Metallothioneins Improves the Disease Course in a Mouse Model of Amyotrophic Lateral Sclerosis
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- Metallothionein Induction in Response to Restraint Stress
- Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis
- Signaling events for metallothionein induction.
- The polymorphism in the promoter region of metallothionein 1 is associated with heat tolerance of scallop Argopecten irradians.
- Cloning and functional characterization of 5'-upstream region of metallothionein-I gene from crucian carp (Carassius cuvieri).
- Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy.
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