Structure of a β1-adrenergic G protein-coupled receptor
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Summary
G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets and here the 2.7 Å resolution crystal structure of a β1-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol is reported.
- Type
- article
- Published
- 2008-06-25
- Cited by
- 1,189
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1908561802
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4394287
Keywords
Transmembrane domain, G protein-coupled receptor, Receptor, Chemistry, Rhodopsin
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- β1-Selective Agonist (−)-1-(3,4-Dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(−)-RO363] Differentially Interacts with Key Amino Acids Responsible for β1-Selective Binding in Resting and Active States
Cited by
- The Role of Protein Structural Analysis in the Next Generation Sequencing Era
- Mammalian G-protein-coupled receptor expression in Escherichia coli: I. High-throughput large-scale production as inclusion bodies.
- Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models
- A G protein-coupled receptor at work: the rhodopsin model.
- Transmembrane signaling by GPCRs: insight from rhodopsin and opsin structures.
- Structural insights into agonist-induced activation of G-protein-coupled receptors.
- Functional selectivity in GPCR signaling: understanding the full spectrum of receptor conformations.
- GPCR activation: a mutagenic spotlight on crystal structures.
- Novel Computational Methodologies for Structural Modeling of Spacious Ligand Binding Sites of G-Protein-Coupled Receptors: Development and Application to Human Leukotriene B4 Receptor
- Beyond Standard Molecular Dynamics: Investigating the Molecular Mechanisms of G Protein-Coupled Receptors with Enhanced Molecular Dynamics Methods
- Structure-function studies of the metabotropic glutamate receptor type 6 (mGluR6) and comparison with rhodopsin
- Structural features of β2 adrenergic receptor: crystal structures and beyond.
- A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions
- The family of G protein-coupled receptors: an example of membrane proteins.
- Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes.
- Nouveaux concepts dans la pharmacologie des récepteurs aux acides gras à chaîne courte FFA2 et FFA3
- Investigation of the activation mechanism and structural characterization of the CGRP receptor
- Advanced Protein Modeling Method: Benchmarking and Applications in Computer-Aided Drug Discovery
- Structure and dynamics of G-protein coupled receptors.
- Semliki forest virus-based expression of recombinant GPCRs.
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