Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis.
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Summary
It is shown that overexpression of Notch1 was able to inhibit the growth of HCC cells in vitro and in vivo, and suggest that Notch 1 signaling may participate in the development of H CC cells, affecting multiple pathways that control both cell proliferation and apoptosis.
- Type
- article
- Published
- 2003-12-01
- Cited by
- 266
- References
- 45
- OpenAlex
- https://openalex.org/W1722577819
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29765628
Keywords
Cyclin D1, Cancer research, Cell cycle, Carcinogenesis, Biology
References
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- Involvement of ERK, p38 and NF‐κB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells
- Notch1 functions as a tumor suppressor in mouse skin
- Inhibition of granulocytic differentiation by mNotch1.
- Identification of Notch1 as a Frequent Target for Provirus Insertional Mutagenesis in T-Cell Lymphomas Induced by Leukemogenic Mutants of Mouse Mammary Tumor Virus
- Sustained activation of AMP‐activated protein kinase induces c‐Jun N‐terminal kinase activation and apoptosis in liver cells
- Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation.
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- Platelets promote the adhesion of human hepatoma cells with a highly metastatic potential to extracellular matrix protein: involvement of platelet P-selectin and GP IIb-IIIa
- Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.
- Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome.
- A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes.
Cited by
- Drug Resistance Mechanisms to Gamma-secretase Inhibitors in Human Colon Cancer Cells
- Notch signaling is necessary for epithelial growth arrest by TGF-β
- Effect of Mesenchymal Stem Cells and a Novel Curcumin Derivative on Notch1 Signaling in Hepatoma Cell Line
- Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives
- NOTCH1 activates the Wnt/β-catenin signaling pathway in colon cancer
- The expression profile and clinicopathological significance of Notch1 in patients with colorectal cancer: a meta-analysis.
- Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication
- Effect of miR-515-5p on Proliferation and Drug Sensitivity of Retinoblastoma Cells
- Notch3 intracellular domain accumulates in HepG2 cell line.
- The role of the notch and hedgehog signalling pathways in vascular smooth muscle cell growth
- Hepatic cancer stem cells and drug resistance: Relevance in targeted therapies for hepatocellular carcinoma.
- The role of the notch signalling pathway in vascular smooth muscle cell apoptosis
- C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling
- Molecular signalling in hepatocellular carcinoma: Role of and crosstalk among WNT/ß-catenin, Sonic Hedgehog, Notch and Dickkopf-1.
- Inhibition of γ-secretase by retinoic acid chalcone (RAC) induces G2/M arrest and triggers apoptosis in renal cell carcinoma.
- Charakterisierung der Wechselwirkungen zwischen dem Notch-Signalweg und intrinsischen und extrinsischen Signalen in hämatopoetischen Zellen
- The effect of pulsatile flow on co-cultured retinal endothelial & pericyte cells
- Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.
- Delaying vascular aging with chinese medicine: Implications from an overview of the p53 and miR-34s family
- The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours
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