Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
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Summary
It is shown that freshly biopsied normal human brain contains abundant αS tetramers and that αS mutations associated with familial PD decrease the intraneuronal tetramer:monomer ratio and are correlated with neurotoxicity.
- Type
- article
- Published
- 2015-06-16
- Cited by
- 304
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W1886318170
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205337660
Keywords
Tetramer, Missense mutation, Neurotoxicity, Monomer, Chemistry
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Cited by
- Transient β-hairpin formation in α-synuclein monomer revealed by coarse-grained molecular dynamics simulation.
- Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
- New insights into cellular α-synuclein homeostasis in health and disease.
- The native form of α‐Synuclein: Monomer, tetramer, or a combination in equilibrium
- Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson’s Disease
- From intrinsically disordered protein to context-dependent folding: The α-synuclein tetramer is teased out of hiding
- Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease
- Review: Sporadic Parkinson's disease: development and distribution of α‐synuclein pathology
- Parkinson disease: Disease-linked morphometric variants of α-synuclein
- Dynamic structural flexibility of α-synuclein
- Synaptic failure and α‐synuclein
- Structural disorder of monomeric α-synuclein persists in mammalian cells
- ɑ‐Synuclein strains and the variable pathologies of synucleinopathies
- GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum.
- X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers
- Characterization of α-Synuclein Multimer Stoichiometry in Complex Biological Samples by Electrophoresis
- Pharmakotherapie des Parkinson
- How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson’s disease?
- The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication
- shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity
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