Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding
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Summary
A unique, tandem IgG1/IgA2 antibody format in the context of a trastuzumab variable domain that exhibits enhanced ADCC and ADCP capabilities is described, which could potentially augment IgG-based immunotherapeutics with enhanced PMN-mediated cytotoxicity while avoiding many of the problems associated with developing IgAs.
- Type
- article
- Published
- 2015-05-13
- Cited by
- 63
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W1878923342
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5053855
Keywords
Antibody-dependent cell-mediated cytotoxicity, Fragment crystallizable region, Antibody, Cytotoxicity, Isotype
References
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- Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity
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- A Novel Human IgA Monoclonal Antibody Protects against Tuberculosis
- Antibodies and cancer therapy: versatile platforms for cancer immunotherapy
- Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions
- The IgA system: a comparison of structure and function in different species.
- Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity.
- The surface membrane antigen phenotype of human blood basophils
- Hybrid IgA2/IgG1 antibodies with tailor-made effector functions.
- Immunoglobulin A: Fc(alpha)RI interactions induce neutrophil migration through release of leukotriene B4.
- Cellular distribution, regulation, and biochemical nature of an Fc alpha receptor in humans
- IgGA: a "cross-isotype" engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions.
- The human Fc receptor for IgA (Fc alpha RI, CD89) on transgenic peritoneal macrophages triggers phagocytosis and tumor cell lysis.
Cited by
- The era of the immunoglobulin A Fc receptor FcαRI; its function and potential as target in disease
- A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA
- Immunoglobulin isotype knowledge and application to Fc engineering.
- Successive site translocating inoculation potentiates DNA/recombinant vaccinia vaccination
- Enhancement of Immune Effector Functions by Modulating IgG’s Intrinsic Affinity for Target Antigen
- Neutrophils in cancer
- Immunoglobulin A: magic bullet or Trojan horse?
- Enhancement of antibody functions through Fc multiplications
- Simultaneous exposure to FcγR and FcαR on monocytes and macrophages enhances antitumor activity in vivo
- Antibody-Based Cancer Therapy: Successful Agents and Novel Approaches.
- Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields
- Therapeutic Antibodies: What Have We Learnt from Targeting CD20 and Where Are We Going?
- Use of Monoclonal Antibodies to Prevent the Sexual Transmission of Human Immunodeficiency Virus Type 1
- Monoclonal antibody‐mediated killing of tumour cells by neutrophils
- Overcoming Resistance to Natural Killer Cell Based Immunotherapies for Solid Tumors
- Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG
- Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice
- Considerations for the Design of Antibody-Based Therapeutics
- Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life
- IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47–SIRPα Checkpoint Inhibition
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