Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding

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Summary

A unique, tandem IgG1/IgA2 antibody format in the context of a trastuzumab variable domain that exhibits enhanced ADCC and ADCP capabilities is described, which could potentially augment IgG-based immunotherapeutics with enhanced PMN-mediated cytotoxicity while avoiding many of the problems associated with developing IgAs.

Type
article
Published
2015-05-13
Cited by
63
References
45
Access
Open access

Keywords

Antibody-dependent cell-mediated cytotoxicity, Fragment crystallizable region, Antibody, Cytotoxicity, Isotype

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