Ligand endocytosis drives receptor dissociation and activation in the Notch pathway.

Keywords

Endocytosis, Cell biology, Dynamin, Biology, Notch signaling pathway

References

• Nuclear access and action of notch in vivo.F. J. Di Mario — 1998
• Notch receptors, partners and regulators: from conserved domains to powerful functions.Sean E. Egan, Benoit St‐Pierre, Ching Ching Leow — 1998
• Cell surface proteins of Drosophila. I. Changes induced by 20-hydroxyecdysone.Daniel F. Woods, Clifton A. Poodry — 1983
• The Genome of Drosophila MelanogasterDan L. Lindsley, Georgianna G. Zimm — 1992
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domainEric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan — 1998
• Processing of the notch ligand delta by the metalloprotease Kuzbanian.Huilin Qi, Matthew D. Rand, Xiaohui Wu — 1999
• The pleiotropic function of Delta during postembryonic development of Drosophila melanogaster.Todd R Parody, Marc A. T. Muskavitch — 1993
• Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.R J Diederich, Kenji Matsuno, Huey Hing — 1994
• Cell lines derived from late embryonic stages of Drosophila melanogaster.Imogene Schneider — 1972
• Delta-notch signaling and Drosophila cell fate choice.Marc A. T. Muskavitch — 1994
• shibire, a neurogenic mutant of Drosophila.Clifton A. Poodry — 1990
• Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.Ilaria Rebay, R.J. Fleming, Richard G. Fehon — 1991
• Notch/LIN-12 signaling: transduction by regulated protein slicing.Judith Kimble — 1998
• The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster.Annette L. Parks, Stacey S. Huppert, Marc A. T. Muskavitch — 1997
• Developmental properties of Shibire: a pleiotropic mutation affecting larval and adult locomotion and development.Clifton A. Poodry, Linda M. Hall, David T Suzuki — 1973
• Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene DeltaAjay Chitnis, Domingos Henrique, Julian Lewis — 1995
• Phylogenetic analysis of vertebrate and invertebrate Delta/Serrate/LAG-2 (DSL) proteins.James L. Lissemore, William T. Starmer — 1999
• Single amino acid substitutions in EGF-like elements of Notch and Delta modify Drosophila development and affect cell adhesion in vitro.Toby Lieber, Cedric S. Wesley, Elizabeth Alcamo — 1992
• Dimerization of cell surface receptors in signal transductionCarl‐Henrik Heldin — 1995
• Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development.Annette L. Parks, F. Rudolf Turner, Marc A. T. Muskavitch — 1995

Cited by

• Functional Characterization of the Presenilin Homologue SPE-4Aya Yamasaki-Meythaler — 2006
• A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.Dmitry G. Kiryan, G. V. Kiryan — 2000
• An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.章伸 寺本, 龍文 濱田, 浩史 赤堀 — 2002
• Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.Akiko Ogawa Kawata — 2003
• Trypanosoma cruzi invasion is associated with trogocytosisPer Aage Brandt — 2014
• Notch Signaling in Development, Tissue Homeostasis, and Disease.Patrícia Afonso Barroso — 2017
• Endocytosis and intracellular trafficking of Notch and its ligands.Shinya Yamamoto, Wu‐Lin Charng, Hugo J. Bellen — 2010
• Notch in malignancy.Douglas W. Ball, Steven D. Leach — 2003
• The Role of Adams in Notch SignalingArjan J. Groot, Marc Vooijs — 2012
• Targeting the Notch-1/IGF-1R/Akt Axis in at Orthotopic Model of Advanced Non-Small Cell Lung CancerS. Liang — 2013
• CD28 costimulation in T cells : requirements, outcomes and regulationZoe Briggs — 2014
• Notch: a membrane-bound transcription factor.Raphael Kopan — 2002
• Role of Delta-like-3 in mammalian somitogenesis and vertebral column formation.Gavin Chapman, Sally L. Dunwoodie — 2008
• A study of Notch signalling in developmental angiogenesisL.-K. Phng — 2009
• Notch signaling : From receptor cleavage to chromatin remodelingKia Strömberg — 2005
• Novel Role of ErbB-2 in Inhibition of Jagged-1-Mediated Trans-Activation of Notch in Breast CancerKinnari Pandya — 2013
• Developmental regulation through protein stability.Janice A. Fischer — 2002
• The role of hes genes in the controlled production of neuronsR. Fior — 2007
• Sara-binding proteins and their role during asymmetric cell divisionM. Merlo, A. Belén — 2011
• The role of the notch and hedgehog signalling pathways in vascular smooth muscle cell growthD. Morrow — 2006

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