Role of Delta-like-3 in mammalian somitogenesis and vertebral column formation.
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Summary
This work discusses what is known about the expression and function of this ligand, Delta-like-3, during somitogenesis and vertebral column formation in mouse and humans.
- Type
- review
- Published
- 2008-12-06
- Cited by
- 3
- References
- 154
- OpenAlex
- https://openalex.org/W68860186
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7742089
Keywords
Somitogenesis, Somite, Vertebral column, Notch signaling pathway, Axial skeleton
References
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- p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1
- Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
- Reconstitution of γ-secretase activity
- Defects in somite formation in lunatic fringe-deficient mice
- The making of the somite: molecular events in vertebrate segmentation
- The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila
- lunatic fringe is an essential mediator of somite segmentation and patterning
- The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries
- Mesp2 initiates somite segmentation through the Notch signalling pathway
- Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis
- A cluster of autosomal recessive spondylocostal dysostosis caused by three newly identified DLL3 mutations segregating in a small village
- A molecular clock involved in somite segmentation.
- Pseudodominant inheritance of spondylocostal dysostosis type 1 caused by two familial delta‐like 3 mutations
- Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
- Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
- Processing of the notch ligand delta by the metalloprotease Kuzbanian.
- The migration of neural crest cells and the growth of motor axons through the rostral half of the chick somite.
- Ligand endocytosis drives receptor dissociation and activation in the Notch pathway.
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