Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.

Keywords

Adoptive cell transfer, CD8, Immune system, Biology, Cancer research

References

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Cited by

• Cbl-b Regulates Antigen-Induced TCR Down-Regulation and IFN-γ Production by Effector CD8 T Cells without Affecting Functional Avidity1M. Hossein Shamim, Som G. Nanjappa, Anju Singh — 2007
• Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b–Regulated T Cell FunctionsMagdalena Paolino, Christine B.F. Thien, Thomas Gruber — 2011
• Enhanced Function of Redirected Human T Cells Expressing Linker for Activation of T Cells That Is Resistant to UbiquitylationNaoki Kunii, Yangbing Zhao, Shuguang Jiang — 2013
• An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.Yuanyuan Zha, Thomas F. Gajewski — 2007
• Engineering effective T-cell based antitumor immunityThomas Gruber, Reinhard Hinterleitner, Christa Pfeifhofer‐Obermair — 2013
• Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol KinasesMatthew J. Riese, Liang‐Chuan S. Wang, Edmund K. Moon — 2013
• Releasing the Brake: Targeting Cbl-b to Enhance Lymphocyte Effector FunctionsStephanie Wallner, Thomas Gruber, Gottfried Baier — 2012
• Cbl-b in T-cell activationMagdalena Paolino, Josef Penninger — 2010
• Defective T‐cell receptor‐induced apoptosis of T cells and rejection of transplanted immunogenic tumors in p53−/− miceNagendra Singh, Lei Huang, Haiyan Qin — 2010
• Silencing the expression of Cbl‐b enhances the immune activation of T lymphocytes against RM‐1 prostate cancer cells in vitroShu-Kui Zhou, Weihua Chen, Zheng-Duo Shi — 2014
• Research Highlights: Highlights from the latest articles in immunomodulationClaudia Cocco, Irma Airoldi — 2012
• Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma ModelReinhard Hinterleitner, Thomas Gruber, Christa Pfeifhofer‐Obermair — 2012
• Reinforcement of cancer immunotherapy by adoptive transfer of cblb‐deficient CD8+ T cells combined with a DC vaccineChristina Lutz‐Nicoladoni, Stephanie Wallner, Patrizia Stoitzner — 2012
• Negative regulation of lymphocyte development and function by the Cbl family of proteinsFang Huang, Hua Gu — 2008
• Cbl exposes its RING fingerStephen C. Kales, Philip Ryan, Stanley Lipkowitz — 2012
• Decreased Diacylglycerol Metabolism Enhances ERK Activation and Augments CD8+ T Cell Functional Responses*Matthew J. Riese, Jashanpreet Grewal, Jayajit Das — 2010
• Modulation of Immune Cell Functions by the E3 Ligase Cbl-bChristina Lutz‐Nicoladoni, Dominik Wolf‎, Sieghart Sopper — 2015
• E3 ubiquitin ligase Cbl-b in innate and adaptive immunityLiu Qingjun, Hong Zhou, Wallace Y. Langdon — 2014
• Mammary tumors with diverse immunological phenotypes show differing sensitivity to adoptively transferred CD8+ T cells lacking the Cbl-b geneTaimei Yang, Michele L. Martin, Julie S. Nielsen — 2009
• PKC-θ Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and DegradationThomas Gruber, Natascha Hermann‐Kleiter, Reinhard Hinterleitner — 2009

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