Involvement of mitogen‐activated protein kinase and NF‐κB signaling pathways in perfluorooctane sulfonic acid‐induced inflammatory reaction in BV2 microglial cells
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Summary
It is suggested that PFOS exerts its functional effects on the response of microglial cell activation via, in part, the c‐Jun N‐terminal protein kinase, ERK and NF‐κB signaling pathways with its subsequent influence on proinflammatory action.
- Type
- article
- Published
- 2015-12-01
- Cited by
- 31
- References
- 69
- OpenAlex
- https://openalex.org/W1844485084
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25860027
Keywords
Chemistry, Signal transduction, Protein kinase A, Kinase, Cell biology
References
- Determination of perfluorooctanoic acid and perfluorooctanesulfonate in human tissues by liquid chromatography/single quadrupole mass spectrometry.
- Effects of Microenvironment on Morphology and Function of the Microglial Cell Line BV-2
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- Inhibition of inducible NO synthase, cyclooxygenase‐2 and interleukin‐1β by torilin is mediated by mitogen‐activated protein kinases in microglial BV2 cells
- CD40-Mediated Transcriptional Regulation of the IL-6 Gene in B Lymphocytes: Involvement of NF-κB, AP-1, and C/EBP1
- Crosstalk in NF-κB signaling pathways
- Extracellular Signal-Regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-α Gene Expression in Endotoxin-Stimulated Primary Glial Cultures
- Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells.
- Mechanisms Underlying Inflammation in Neurodegeneration
- Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells
- Perfluoroalkyl sulfonic and carboxylic acids: A critical review of physicochemical properties, levels and patterns in waters and wastewaters, and treatment methods
- Growing concern over perfluorinated chemicals.
- Perfluorooctane sulfonate-induced apoptosis of cerebellar granule cells is mediated by ERK 1/2 pathway.
- Transcriptional regulation of the tumor necrosis factor alpha gene.
- Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis
- Perfluorooctane sulfonate triggers tight junction "opening" in brain endothelial cells via phosphatidylinositol 3-kinase.
- Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers
- Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance
- Perfluorooctanoic acid induces mast cell-mediated allergic inflammation by the release of histamine and inflammatory mediators.
Cited by
- The PFOS disturbed immunomodulatory functions via nuclear Factor-κB signaling in liver of zebrafish (Danio rerio).
- Anti-inflammatory effects of glaucocalyxin B in microglia cells.
- α-Tocopherol-ascorbic acid hybrid antioxidant based cationic amphiphile for gene delivery: Design, synthesis and transfection.
- Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
- Assessment on the adverse effects on different kinds of fish induced by methamphetamine during the natural attenuation process based on adverse outcome pathway.
- Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS.
- Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms
- Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework
- Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells
- Perfluorooctane sulfonate promotes atherosclerosis by modulating M1 polarization of macrophages through the NF-κB pathway.
- Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS)
- A review on structural mechanisms of protein-persistent organic pollutant (POP) interactions.
- 5-HMF attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis mice by inhibiting the MIF-CD74 interaction
- Association between a mixture of per-and polyfluoroalkyl substances (PFAS) and inflammatory biomarkers in the Atlanta African American Maternal-Child Cohort
- Identification of the mechanisms underlying per- and polyfluoroalkyl substance-induced hippocampal neurotoxicity as determined by network pharmacology and molecular docking analyses.
- Early-life exposure to perfluoroalkyl substances and serum antibody concentrations towards common childhood vaccines in 18-month-old children in the Odense Child cohort.
- Per- and Polyfluoroalkyl Substances Alter Innate Immune Function: Evidence and Data Gaps
- Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner
- Flaxseed Oil Alleviates PFOS-Induced Liver Injury by Regulating Hepatic Cholesterol Metabolism.
- Maternal exposure to per- and polyfluoroalkyl substances and epitope level antibody response to vaccines against measles and rubella in children from the Boston birth cohort
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