Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Defines the Composition and Structure of MHC Class I Peptide Repertoire in Normal and Virus-Infected Cells
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Summary
This study determined the amino acid sequences of a large number of naturally processed peptides in mice lacking the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP) and found that ERAAP-deficiency changed the oeuvre and caused a marked increase in the length of peptides normally presented by MHC-I.
- Type
- article
- Published
- 2010-02-19
- Cited by
- 104
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1809576401
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:695436
Keywords
MHC class I, Endoplasmic reticulum, Transporter associated with antigen processing, Biology, Major histocompatibility complex
References
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- Genetics and the pathogenesis of ankylosing spondylitis
- Antigen Processing and Presentation Protocols
- Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
- ER aminopeptidases generate a unique pool of peptides for MHC class I molecules
- Large Scale Mass Spectrometric Profiling of Peptides Eluted from HLA Molecules Reveals N-Terminal-Extended Peptide Motifs1
- Murine Cytomegalovirus Interference with Antigen Presentation Has Little Effect on the Size or the Effector Memory Phenotype of the CD8 T Cell Response1
- Basic methods in molecular biology
- The optimization of peptide cargo bound to MHC class I molecules by the peptide‐loading complex
- Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
- The group II chaperonin TRiC protects proteolytic intermediates from degradation in the MHC class I antigen processing pathway.
- Post-proteasomal antigen processing for major histocompatibility complex class I presentation
- Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa.
- Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.
- The quality control of MHC class I peptide loading
- Interaction of ERp57 and tapasin in the generation of MHC class I-peptide complexes.
- TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.
- Using ubiquitin to follow the metabolic fate of a protein.
- Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.
- Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.
Cited by
- Sculpting MHC class II-restricted self and non-self peptidome by the class I antigen-processing machinery and its impact on CD4+ TCR repertoire and Th cell responses
- Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation
- Peptide Repertoire Changes Caused by Defects in Antigen Processing
- Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA–B27
- Structural Basis For Antigenic Peptide Precursor Processing by the Endoplasmic Reticulum Aminopeptidase ERAP1
- Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases.
- Sequence-specific alterations of epitope production by HIV Protease Inhibitors
- Placental Leucine Aminopeptidase Efficiently Generates Mature Antigenic Peptides In Vitro but in Patterns Distinct from Endoplasmic Reticulum Aminopeptidase 1
- ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role
- Non-classical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum
- ERAAP modulation: A possible novel strategy for cancer immunotherapy?
- Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection
- Immunodominance: a pivotal principle in host response to viral infections.
- Origin and plasticity of MHC I-associated self peptides.
- Immune surveillance for ERAAP dysfunction
- Antigenic peptide trimming by ER aminopeptidases – insights from structural studies
- Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell response by targeting the aminopeptidase ERAP1
- The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies.
- Location of the CD8 T Cell Epitope within the Antigenic Precursor Determines Immunogenicity and Protection against the Toxoplasma gondii Parasite
- Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer
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