Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells
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Summary
These studies identify a novel mechanism and pathway of HGF signalling in endothelial cells involving cooperation between Met and integrins in a Ras dependent manner and have implications for the regulation of neovascularization in both health and disease.
- Type
- article
- Published
- 2005-02-17
- Cited by
- 163
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1808819173
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:260934292
Keywords
Cell biology, Integrin, Biology, Fibronectin, Angiogenesis
References
- Hepatocyte growth factor-induced endothelial cell motility is mediated by the upregulation of inducible nitric oxide synthase expression.
- Angiogenesis in cancer and other diseases
- Phosphatidylinositol-3-OH kinase direct target of Ras
- Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation.
- A Molecular Mechanism of Integrin Crosstalk: αvβ3 Suppression of Calcium/Calmodulin-dependent Protein Kinase II Regulates α5β1 Function
- Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.
- Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A.
- A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth.
- Role of phosphoinositide 3OH‐kinase in autocrine transformation by PDGF‐BB *
- Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
- Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis.
- Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor‐2
- Eph B4 Receptor Signaling Mediates Endothelial Cell Migration and Proliferation via the Phosphatidylinositol 3-Kinase Pathway*
- Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells*
- Prognostic Significance of Angiogenic Growth Factor Serum Levels in Patients With Acute Coronary Syndromes
- Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
- Fibronectin promotes VEGF-induced CD34 cell differentiation into endothelial cells.
- Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors
- Apoptotic cues from the extracellular matrix: regulators of angiogenesis
- Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis.
Cited by
- Cell Adhesion Biophysics on Dynamic Polymer Constructs
- Mechanochemical regulation of growth cone motility
- Regulation of TGF-B1-induced apoptosis and epithelial-mesenchymal transition by matrix rigidity
- Host Signaling Response to Adhesion of Bifidobacterium infantis
- Dentine extracellular matrix components liberated by calcium silicate cements and their effects on dental pulp cells
- The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship.
- Bustle behind the scenes of action: nemosis as a model for fibroblast inflammatory activation
- Chimeric vitronectin:insulin-like growth factor proteins enhance cell growth and migration through co-activation of receptors
- Vascular tube formation on matrix metalloproteinase-1-damaged collagen
- Improved strategies for the cultivation of human limbal epithelial (HLE) grafts
- Vitronectin—Master controller or micromanager?
- TARTRATE RESISTANT ACID PHOSPHATASE 5A: A POTENTIAL REGULATOR OF ADIPOCYTE CELL NUMBER AND DIFFERENTIATION IN WHITE ADIPOSE TISSUE
- Extracellular matrix: not just pretty fibrils
- Cellular Reporter Systems for High-Throughput Screening of Interactions Between Bioactive Matrices and Human Mesenchymal Stromal Cells
- Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing
- A functional characterisation of the dimerisation motif in fibronectin, in vivo and in vitro
- The effect of dentine conditioning agents on solubilisation of bioactive dentine matrix components and dentine regeneration
- The myofibroblast matrix: implications for tissue repair and fibrosis
- BRAF inhibition generates a host/tumor niche that mediates therapeutic escape
- Cooperation between integrin αvβ3 and VEGFR2 in angiogenesis
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