In vivo evidence that secretion of HLA‐G by immunogenic tumor cells allows their evasion from immunosurveillance
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Summary
This study provides the first in vivo proof that soluble HLA‐G counteracts tumor rejection and reinforces the importance to consider Hla‐G as a promising target to optimize current cancer immunotherapies.
- Type
- article
- Published
- 2014-11-01
- Cited by
- 76
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W1794357844
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13234022
Keywords
Immunosurveillance, Biology, Immune system, Antigen, Immunology
References
- Interferons, immunity and cancer immunoediting
- Evidence to Support the Role of HLA-G5 in Allograft Acceptance through Induction of Immunosuppressive/ Regulatory T Cells1
- HLA‐G1 and HLA‐G5 active dimers are present in malignant cells and effusions: The influence of the tumor microenvironment
- Suppression, subversion and escape: the role of regulatory T cells in cancer progression
- Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice
- Human melanoma cell secreting human leukocyte antigen-G5 inhibit natural killer cell cytotoxicity by impairing lytic granules polarization toward target cell.
- Switch of HLA‐G alternative splicing in a melanoma cell line causes loss of HLA‐G1 expression and sensitivity to NK lysis
- Neoplastic B-cell growth is impaired by HLA-G/ILT2 interaction
- Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.
- Tumor angiogenesis: molecular pathways and therapeutic targets
- Myeloid-derived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasL.
- Tolerization of dendritic cells by HLA‐G
- HLA‐G expression is associated with metastasis and poor survival in the Balb/c nu/nu murine tumor model with ovarian cancer
- Myeloid-derived-suppressor cells as regulators of the immune system
- Local targets for immune therapy to cancer: Tumor draining lymph nodes and tumor microenvironment
- Mobilizing dendritic cells for tolerance by engagement of immune inhibitory receptors for HLA-G.
- Inhibition of human Vγ9Vδ2 T-cell antitumoral activity through HLA-G: implications for immunotherapy of cancer
- Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17.
- Soluble HLA‐G molecules impair natural killer/dendritic cell crosstalk via inhibition of dendritic cells
- Expression of functional soluble human leucocyte antigen‐G molecules in lymphoproliferative disorders
Cited by
- Qa-2 expression levels is related with tumor-infiltrating lymphocytes profile during solid Ehrlich tumor development.
- HLA-G: An Immune Checkpoint Molecule.
- The Dual Role of HLA-G in Cancer
- Significance of tumour cell HLA-G5/-G6 isoform expression in discrimination for adenocarcinoma from squamous cell carcinoma in lung cancer patients
- Lesion HLA-G5/-G6 isoforms expression in patients with ovarian cancer.
- Association of HLA-G +3142 C>G polymorphism and breast cancer in Tunisian population
- Co-expression of ILT4/HLA-G in human non-small cell lung cancer correlates with poor prognosis and ILT4-HLA-G interaction activates ERK signaling
- Pregnancy and breastfeeding: a new theory for sHLA-G in breast cancer patients?
- Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma
- Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy
- Regulation of neutrophil functions through inhibitory receptors: an emerging paradigm in health and disease
- Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases
- Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2
- Potential Roles of HLA-G and MDSCs in Virus Infection
- Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape
- HLA‐G promotes myeloid‐derived suppressor cell accumulation and suppressive activity during human pregnancy through engagement of the receptor ILT4
- HLA-G and Virus Infection
- Importance of the plasma soluble HLA-G levels for prognostic stratification with traditional prognosticators in colorectal cancer
- Tuning cancer fate: the unremitting role of host immunity
- Intratumor heterogeneity of immune checkpoints in primary renal cell cancer: Focus on HLA-G/ILT2/ILT4
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