The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod
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Summary
The potential for re‐purposing FTY720, an immunomodulatory drug recently approved for the treatment of multiple sclerosis, shows efficacy as an anti‐cancer agent both in vitro and in vivo.
- Type
- review
- Published
- 2015-07-14
- Cited by
- 56
- References
- 118
- Access
- Open access
- OpenAlex
- https://openalex.org/W1793691728
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17167866
Keywords
Fingolimod, Pharmacology, Sphingosine, Drug repositioning, Signal transduction
References
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- Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer
- The sphingosine kinase inhibitor 2‐(p‐hyroxyanilino)‐4‐(p‐chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress‐dependent mechanism
- FTY720 Inhibits Tumor Growth and Enhances the Tumor-Suppressive Effect of Topotecan in Neuroblastoma by Interfering With the Sphingolipid Signaling Pathway
- Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis
- PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
- PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis
- FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.
- The Immune Modulator FTY720 Inhibits Sphingosine-1-phosphate Lyase Activity*
- Enhancement of Neoangiogenesis and Follicle Survival by Sphingosine-1-Phosphate in Human Ovarian Tissue Xenotransplants
- A novel liposomal formulation of FTY720 (Fingolimod) for promising enhanced targeted delivery
- FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells
- Anti-CD25 (daclizumab) monoclonal antibody therapy in relapsing-remitting multiple sclerosis.
- FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase.
- Cellular and metabolic functions for autophagy in cancer cells
- Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite.
- Sphingosine-1-Phosphate Receptor 1 in Classical Hodgkin Lymphoma: Assessment of Expression and Role in Cell Migration
Cited by
- Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer
- Addressing the Potential Role of Fingolimod in Cancer Therapy
- Potential anti-tumor effects of FTY720 associated with PP2A activation: a brief review
- Novel cancer-related regulatory targets for the signalling sphingolipids sphingosine-1-phosphate and sphingosylphosphorylcholine
- Comment on Goldsworthy et al. Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes. Diabetes 2016;65:1434–1446
- Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2
- Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs
- Distinct mechanisms of B and T lymphocyte accumulation generate tumor-draining lymph node hypertrophy
- The Role of PME-1 in Cancer: Therapeutic Implication
- Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism
- To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling.
- Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma
- Phosphorylation as a mediator of protein function in cell migration, differentiation, and death : vimentin, AATF, and Par-4 in the spotlight
- A Systems Biology Analysis of PP2A Functions in Cancer Cells
- Mechanisms of sphingosine 1-phosphate receptor signalling in cancer.
- FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model
- Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy
- Design, synthesis and biological evaluation of new pyrrolidine carboxamide analogues as potential chemotherapeutic agents for hepatocellular carcinoma.
- Sphingosine 1-Phosphate Signaling and Its Pharmacological Modulation in Allogeneic Hematopoietic Stem Cell Transplantation
- Mechanisms of B and T lymphocyte accumulation in tumor-draining lymph nodes
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