A new computational method for detection of chimeric 16S rRNA artifacts generated by PCR amplification from mixed bacterial populations

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Summary

This study suggests that k-tuple-based matching methods are more sensitive than alignment-based methods when there is significant parental sequence similarity, while the opposite becomes true as the sequences become more distantly related.

Type
article
Published
1997-06-01
Cited by
57
References
24
Access
Open access

Keywords

Chimera (genetics), Computational biology, Bacterial artificial chromosome, Sequence alignment, Biology

References

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