Analysis of the effects of lipopolysaccharide on macrophages: differential phagocytic responses of C3H/HeN and C3H/HeJ macrophages in vitro
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Summary
This assay represents an extremely sensitive method for analyzing the direct effects of LPS on macrophage cytotoxicity and demonstrates that LPS induces a profound inhibition of Fc-mediated phagocytosis in LPS responsive macrophages.
- Type
- article
- Published
- 1979-07-01
- Cited by
- 46
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W1787488447
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36696635
Keywords
Phagocytosis, Lipopolysaccharide, Macrophage, Cytotoxicity, Trypan blue
References
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- Resistance of macrophages from C3H/HeJ mice to the in vitro cytotoxic effects of endotoxin.
- The inflammatory response and resistance to endotoxin in mice.
- Characterization of a congenitally LPS-resistant, athymic mouse strain.
- Effect of prostaglandins on phagocytosis of sheep erythrocytes by mouse peritoneal macrophages.
- Relation of structure to function in bacterial endotoxins. VIII. Biological activities in a polysaccharide-rich fraction.
- Macrophage sensitivity to endotoxin: genetic control by a single codominant gene.
- Development and standardization of radioimmunoassays for prostaglandins E, F, and A.
- Defective prostaglandin synthesis by C3H/HeJ mouse macrophages stimulated with endotoxin preparations
- PHYSICOCHEMICAL CHANGES IN ENDOTOXIN ASSOCIATED WITH LOSS OF BIOLOGICAL POTENCY
- In Vitro and In Vivo Effects of Endotoxin on Mouse Peritoneal Cells
- THE SELECTIVE TOXICITY OF ENDOTOXIN FOR PHAGOCYTIC CELLS OF THE RETICULOENDOTHELIAL SYSTEM.
- Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235.
- Cytotoxicity of endotoxin in vitro. Effects on macrophages from normal guinea pigs.
- Prostaglandin regulation of macrophage collagenase production.
- Isolation of a lipid a bound polypeptide responsible for “LPS- initiated” mitogenesis of C3H/HeJ spleen cells
- Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides
- Strain-dependent cytotoxic effects of endotoxin for mouse peritoneal macrophages
Cited by
- The influence of bacterial exotoxins and endotoxins on the phagocytic activity of human macrophages in culture
- Lithium and Cell Physiology
- Lipopolysaccharide and ceramide use divergent signaling pathways to induce cell death in murine macrophages.
- Genetic resistance to flaviviruses.
- Contributions of C1q, bacterial lipopolysaccharide, and porins during attachment and ingestion phases of phagocytosis by murine macrophages
- Nanoparticle distribution during systemic inflammation is size-dependent and organ-specific.
- Lipopolysaccharide-induced suppression of phagocytosis: effects on the phagocytic machinery.
- The molecular bases of spontaneous immunological mutations in the mouse and their homologous human diseases.
- Macrophages migration inhibition by complement activators, migration inhibitory factor, and Lotus fucolectin: evidence for common involvement of cell-associated esterase activity.
- Gangliosides block the inhibition of macrophage Fc-dependent phagocytosis by lipopolysaccharide.
- Lipopolysaccharide significantly enhances erythrophagocytosis but marginally stimulates the phagocytosis of Staphylococcus aureus in mouse peritoneal macrophages.
- Opposite effects of bacterial lipopolysaccharide on Fc-receptor-mediated phagocytosis of two bone marrow-derived macrophage cell lines, BDM-1 and BDM-1W3.
- Prostaglandin regulation of macrophage function: effect of endogenous and exogenous prostaglandins.
- The Lps locus: Genetic regulation of host responses to bacterial lipopolysaccharide
- BCG-induced enhancement of endotoxin sensitivity in C3H/HeJ mice. II. T cell modulation of macrophage sensitivity to LPS in vitro.
- Pulmonary macrophage antimicrobial activity in canine endotoxin shock and lung injury.
- End-stage dying glioma cells are engulfed by mouse microglia with a strain-dependent efficacy.
- Effect of lipopolysaccharide on the stimulation of macrophage Fc-dependent phagocytosis by splenic B lymphocytes.
- Uptake and deacylation of bacterial lipopolysaccharides by macrophages from normal and endotoxin-hyporesponsive mice
- Alveolar macrophage phagocytic activity is enhanced with LPS priming, and combined stimulation of LPS and lipoteichoic acid synergistically induce pro-inflammatory cytokines in pigs
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