Hepatobiliary transporters in the pharmacology and toxicology of anticancer drugs.
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Summary
The existence of carrier proteins located in the basolateral and apical membranes of hepatocytes, cholangiocytes and epithelial cells of the ileal mucosa, together with their ability to transport many different drugs, including anticancer drugs, has important pharmacological repercussions.
- Type
- review
- Published
- 2009-01-01
- Cited by
- 12
- References
- 279
- Access
- Open access
- OpenAlex
- https://openalex.org/W137601650
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:36958500
Keywords
Pharmacology, Drug, Xenobiotic, Transporter, Chemistry
References
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- Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism.
- Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA.
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- The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation.
- The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy
- Plasma Membrane Transporters in Modern Liver Pharmacology
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