Identification of novel p53 target genes in ionizing radiation response.
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Summary
Identification and characterization of ionizing radiation-responsive p53 target genes extend the knowledge of the diverse role that p53 plays in the DNA damage response by identifying and characterize genes that are directly regulated by p53.
- Type
- article
- Published
- 2005-09-01
- Cited by
- 111
- References
- 23
- Access
- Open access
- OpenAlex
- https://openalex.org/W1784517069
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16155393
Keywords
Gene, Biology, DNA damage, DNA repair, Ionizing radiation
References
- Analysis of downstream effectors of p53 on cell growth arrest and apoptosis induced by a temperature-sensitive Val138 mutant.
- Analysis of the mammalian gadd45 gene and its response to DNA damage.
- High-throughput screening of chromatin immunoprecipitates using CpG-island microarrays.
- Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways
- WAF1, a potential mediator of p53 tumor suppression.
- The p53MH algorithm and its application in detecting p53-responsive genes
- Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site
- Plk3 Functionally Links DNA Damage to Cell Cycle Arrest and Apoptosis at Least in Part via the p53 Pathway*
- A polymorphic microsatellite that mediates induction of PIG3 by p53
- Cell Cycle Arrest and Apoptosis Induced by Human Polo-Like Kinase 3 Is Mediated through Perturbation of Microtubule Integrity
- E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints.
- Transcriptional response of lymphoblastoid cells to ionizing radiation.
- p53 Binds and Activates the Xeroderma Pigmentosum DDB2 Gene in Humans but Not Mice
- p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs
- The physical association and phosphorylation of Cdc25C protein phosphatase by Prk
- Clinical implications of the p53 tumor-suppressor gene.
- A temperature sensitive mutant of the human p53, Val138, arrests rat cell growth without induced expression of cip1/waf1/sdi1 after temperature shift-down.
- Heterogeneity of Staphylococcus epidermidis in prosthetic joint infections: time to reevaluate microbiological criteria?
- Genome-wide location and function of DNA binding proteins.
- Significance analysis of microarrays applied to the ionizing radiation response
Cited by
- Transcriptional control of human p53-regulated genes
- Investigation of the Cellular and Molecular Mechanisms of Radiation-induced Bystander Effects
- Identification and validation of biodosimetry markers in multiple models of radiation exposure
- Detection of CYP2E1, a genetic biomarker of susceptibility to benzene metabolism toxicity in immortal human lymphocytes derived from the Han Chinese Population.
- NEW TARGET GENES FOR TUMOR SUPPRESSORS p53 AND p73 IN REGENERATING LIVER
- Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo
- Wild‐type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma
- Cancer investigation: A genome perspective
- Modeling signal transduction pathways and their transcriptional response
- Histone Deacetylase Inhibitors Prevent p53-dependent and Independent Bax-Mediated Neuronal Apoptosis Through Two Distinct Mechanisms
- Transcriptional modulation induced by ionizing radiation: p53 remains a central player
- In Vitro Study on Apoptosis Induced by Strontium-89 in Human Breast Carcinoma Cell Line
- Specific-mutational patterns of p53 gene in bladder transitional cell carcinoma among a group of Iraqi patients exposed to war environmental hazards
- αB‐crystallin: A novel p53‐target gene required for p53‐dependent apoptosis
- Toxicity of depleted uranium complexes is independent of p53 activity
- Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions
- Dose- and Time-Dependent Changes in Gene Expression in Human Glioma Cells after Low Radiation Doses
- PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.
- Gene Profiling Characteristics of Radioadaptive Response in AG01522 Normal Human Fibroblasts
- IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes
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