Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
Explore this paper's citation graph
Summary
Although all IL-6-type cytokines signal through the gp130/Jak/STAT pathway, the comparison of their physiological properties shows that they elicit not only similar, but also distinct, biological responses.
- Type
- review
- Published
- 1998-09-01
- Cited by
- 2,276
- References
- 3
- Access
- Open access
- OpenAlex
- https://openalex.org/W1779691448
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24214679
Keywords
Glycoprotein 130, JAK-STAT signaling pathway, Janus kinase, Cell biology, Janus kinase 1
References
Cited by
- Transcriptional regulation in neutrophils: teaching old cells new tricks.
- Molecular Biology of Human Herpesvirus 8: Novel Functions and Virus–Host Interactions Implicated in Viral Pathogenesis and Replication
- C-reactive Protein: A Physiological Activator of Interleukin 6 Receptor Shedding
- Oxidized LDL activates STAT1 and STAT3 transcription factors: possible involvement of reactive oxygen species
- Oncostatin M: signal transduction and biological activity.
- Crystal structure and functional dissection of the cytostatic cytokine oncostatin M.
- Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex.
- Stat3 activation in prostatic carcinomas
- JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes
- Protectieve effecten van T-lymfocyten in MS : Betrokkenheid van LIF
- Comparative Study of gp130 Cytokine Effects on Corticotroph AtT-20 Cells – Redundancy or Specificity of Neuroimmunoendocrine Modulators?
- Soluble interleukin-6 receptor (sIL-6R) in cerebrospinal fluid of patients with inflammatory and non inflammatory neurological diseases.
- Activation of STAT3 signaling in axotomized neurons and reactive astrocytes after fimbria–fornix transection
- Oncostatin M Receptor-mediated Signal Transduction Is Negatively Regulated by SOCS3 through a Receptor Tyrosine-independent Mechanism*
- Gene and protein expression in the myometrium in pregnancy and labor.
- Survival pathways in hypertrophy and heart failure: The gp130-STAT3 axis
- Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer's disease in Chinese Han.
- Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.
- Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism.
- STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma.
Related papers
- Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses.
- Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.
- Myocardial, Hematological, and Placental Disorders Caused by Targeted Disruption of gp130, A Common Signal Transducer for IL-6 Family of Cytokines
- Localization of molecules involved in cytokine receptor signaling in the rat trigeminal ganglion.
- Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells
- Different protein turnover of interleukin-6-type cytokine signalling components.
- General mechanisms of cytokine receptor signaling.
- Inhibition of IL-6 family cytokines by SOCS3
- S-3 : Inhibition of IL-6 family cytokines by SOCS3: Characterizing the mode of inhibition and the basis of its specificity
- Cytokine receptor signalling