Upregulation of adenylate cyclase 3 (ADCY3) increases the tumorigenic potential of cells by activating the CREB pathway
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Summary
This study is the first to report an association of ADCY3 with gastric cancer as well as its tumorigenic potentials and demonstrates that the expression of ADCy3 is regulated through an epigenetic mechanism.
- Type
- article
- Published
- 2013-09-30
- Cited by
- 55
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W1778865428
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18682940
Keywords
CREB, Cancer research, Downregulation and upregulation, Gene knockdown, DNA methylation
References
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- Molecular screening of gastric cancer by proteome analysis
- Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation
- Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
- Role of cAMP in the promotion of colorectal cancer cell growth by Prostaglandin E2
- Pathology and prognosis of gastric carcinoma. Findings in 10,000 patients who underwent primary gastrectomy
- Differential gene expression pattern in early gastric cancer by an integrative systematic approach
- eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer
- Pathology and prognosis of gastric carcinoma
- Biological Convergence of Cancer Signatures
- Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets.
- Pediatric malignancies provide unique cancer therapy targets
- Gene expression analysis of early and advanced gastric cancers
Cited by
- HEK293 in cell biology and cancer research: phenotype, karyotype, tumorigenicity, and stress-induced genome-phenotype evolution.
- Novel robust biomarkers for human bladder cancer based on activation of intracellular signaling pathways
- Papel de la cascada del ácido araquidónico en el control de la proliferación de las células epiteliales intestinales humanas
- Synthetic Lethal Interactions with E-cadherin for Cancer Therapy
- Blood and Intestine eQTLs from an Anti-TNF-Resistant Crohn's Disease Cohort Inform IBD Genetic Association Loci
- Differences in the expression of microRNAs and their predicted gene targets between cauda epididymal and ejaculated boar sperm.
- Rab23 activities and human cancer—emerging connections and mechanisms
- Type 3 adenylyl cyclase: a key enzyme mediating the cAMP signaling in neuronal cilia.
- Adenylyl cyclase 3/adenylyl cyclase‐associated protein 1 (CAP1) complex mediates the anti‐migratory effect of forskolin in pancreatic cancer cells
- Joint QTL mapping and gene expression analysis identify positional candidate genes influencing pork quality traits
- 4-parvifuran inhibits metastatic and invasive actions through the JAK2/STAT3 pathway in osteosarcoma cells
- Characterization of potential driver mutations involved in human breast cancer by computational approaches
- Suxiao Jiuxin Pill protects cardiomyocytes against mitochondrial injury and alters gene expression during ischemic injury
- ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP‐9 expression and transendothelial migration in breast cancer cells
- Elevated Cyclic AMP levels promote BRAFCA/Pten−/− mouse melanoma growth but pCREB is negatively correlated with human melanoma progression
- ADCY3, neuronal primary cilia and obesity
- Tetraspanin family identified as the central genes detected in gastric cancer using bioinformatics analysis
- Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer
- The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype
- Adenosine receptors as novel targets for the treatment of various cancers.
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