Role of free radicals and catalytic metal ions in human disease: an overview.
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Summary
The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
- Type
- review
- Published
- 1990-01-01
- Cited by
- 5,192
- References
- 533
- OpenAlex
- https://openalex.org/W1734082729
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37184319
Keywords
Lipid peroxidation, Radical, Chemistry, Hydrogen peroxide, Antioxidant
References
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- Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA.
- Studies of the limited degradation of mucus glycoproteins. The effect of dilute hydrogen peroxide.
- Regulation of aortic CuZn-superoxide dismutase with copper. Effects in vivo.
Cited by
- The role of lactate dehydrogenase B in aerobic glycolysis-mediated resistance to AB toxicity
- Inhibition of nucleoside transport by reactive oxygen species in bovine heart microvascular endothelial cells.
- Analysis of F2-isoprostanes as indicators of non-enzymatic lipid peroxidation in vivo by gas chromatography-mass spectrometry: development of a solid-phase extraction procedure.
- Nuclear-envelope nucleoside triphosphatase kinetics and mRNA transport following brain ischemia and reperfusion.
- Reactive oxygen species and iron--a dangerous partnership in inflammation.
- Measurement of the oxidisable polyamine content of seminal plasma.
- Intense oxidative DNA damage promoted by l‐DOPA and its metabolites implications for neurodegenerative disease
- Generation and characterization of bioactive peptides from flaxseed ( Linum usitatissimum L.) proteins
- Hydrogen peroxide cytotoxicity under conditions of normal or reduced catalase activity in H2O2-sensitive and -resistant Chinese hamster ovary (CHO) cell variants.
- Effect of tert-butyl hydroperoxide addition on spontaneous chemiluminescence in brain.
- The role of iron-sulfur clusters in in vivo hydroxyl radical production.
- Dehydroepiandrosterone-induced lipid peroxidation in rat liver mitochondria.
- Defects in intracellular oxidative metabolism of neutrophils undergoing apoptosis
- Synaptosomal iron-dependent lipid peroxidation inhibition after subarachnoid hemorrhage by lazaroid in vivo treatment.
- Epidemiological studies on antioxidants, lipid peroxidation and atherosclerosis.
- NAD(P)H oxidase activity in cultured human podocytes: effects of adenosine triphosphate.
- Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates.
- Role of nitric oxide in cellular iron metabolism
- Iron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase C.
- Noninvasive evaluation of in vivo free radical reactions catalyzed by iron using in vivo ESR spectroscopy.
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