Truncation of exon 1 from the c‐myc gene results in prolonged c‐myc mRNa stability.
Explore this paper's citation graph
Summary
The results suggest a role for exon 1 in the c‐myc mRNA degradative mechanism and suggest that this can be a crucial factor in the activation of the c-myc oncogene, byExon 1 loss, in chromosomal translocation.
- Type
- article
- Published
- 1985-12-01
- Cited by
- 143
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W1671772030
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44274384
Keywords
Exon, Biology, Messenger RNA, Gene, Molecular biology
References
No references recorded for this paper.
Cited by
- The same external signal differentially induced the c-myc expression in Burkitt lymphoma and B-lymphoblastoid cell lines.
- The methylation pattern of normal and truncated amplified human c-myc oncogenes.
- A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.
- Ribosomal RNA metabolism in macrophages.
- Studies of secondary transforming events in murine c-myc retrovirus-induced monocyte tumors.
- Control of c-myc regulation in normal and neoplastic cells.
- The myc family of nuclear proto-oncogenes.
- Cloning and characterization of mink plasminogen activator inhibitor type 1 (PAI-1) cDNA and the regulation of mink PAI-1 expression at mRNA level
- Role of AUUU sequences in stabilization of granulocyte-macrophage colony-stimulating factor RNA in stimulated cells.
- Identification of potential oat phytochrome A mRNA degradation mechanisms
- Structural Determinants of mRNA Turnover in Yeast: a Thesis
- Dioctanoylglycerol and phorbol esters regulate transcription of c-myc in human promyelocytic leukemia cells.
- Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family.
- In vitro mRNA degradation system to study the virion host shutoff function of herpes simplex virus
- Reversible suppression of c-myc expression in a human colon carcinoma line by the anticancer agent N-methylformamide.
- Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences
- Activated v-myc and v-ras oncogenes do not transform normal human lymphocytes
- myc family oncogenes in the development of normal and neoplastic cells.
- Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src
- Differential stability of c-myc mRNAS in a cell-free system
Related papers
- Characterization of a novel alternatively-spliced 5' exon in the human insulin-like growth factor I (IGF-I) gene, expressed in liver and some cancers.
- Nitric oxide synthase 1 mRNA: tissue-specific variants from rat with alternative first exons.
- Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1.
- (606): Identification of a novel structure of the μ-opioid receptor gene (OPRM1) through analysis of the GenBank database. A potential new independent peripheral morphine-6-glucoronide receptor
- The Levels of Tau Isoforms Containing Exon-2 and Exon-10 Segments Increased in the Cerebrospinal Fluids of the Patients with Sporadic Creutzfeldt-Jakob Disease
- Alternative usage of exon 1 of bovine PrP mRNA.
- Modulation of Aspirin on Gene Expression and Release of MMP-2/9 and TIMP-1 in Macrophages of Mice