The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate Gyrus In Vivo

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Summary

It is suggested that Elk-1 forms an important link in the MAP kinase pathway to transduce signals from the cell surface to the nucleus to activate the genetic machinery necessary for the maintenance of synaptic plasticity in the dentate gyrus.

Type
article
Published
2000-06-15
Cited by
653
References
51
Access
Open access

Keywords

MAPK/ERK pathway, Long-term potentiation, Cell biology, CREB, Protein kinase A

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