The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate Gyrus In Vivo
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Summary
It is suggested that Elk-1 forms an important link in the MAP kinase pathway to transduce signals from the cell surface to the nucleus to activate the genetic machinery necessary for the maintenance of synaptic plasticity in the dentate gyrus.
- Type
- article
- Published
- 2000-06-15
- Cited by
- 653
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W1660095449
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16269460
Keywords
MAPK/ERK pathway, Long-term potentiation, Cell biology, CREB, Protein kinase A
References
- Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors.
- Synergism in ternary complex formation between the dimeric glycoprotein p67SRF, polypeptide p62TCF and the c‐fos serum response element.
- Direct Evidence for Biphasic cAMP Responsive Element-Binding Protein Phosphorylation during Long-Term Potentiation in the Rat Dentate Gyrus In Vivo
- Journey to the surface of the cell: Fos regulation and the SRE.
- Extracellular Signal-Regulated Kinase (ERK) Controls Immediate Early Gene Induction on Corticostriatal Stimulation
- In Vivo Expression and Regulation of Elk-1, a Target of the Extracellular-Regulated Kinase Signaling Pathway, in the Adult Rat Brain
- Nuclear localization and regulation of erk- and rsk-encoded protein kinases
- The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus
- Nuclear protein CBP is a coactivator for the transcription factor CREB
- A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation*
- Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
- Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning
- The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain.
- Linear relation between the magnitude of long-term potentiation in the dentate gyrus and associative learning in the rat. A demonstration using commissural inhibition and local infusion of an N-methyl-D-aspartate receptor antagonist.
- Requirement of a critical period of transcription for induction of a late phase of LTP.
- Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity.
- Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element.
- Postsynaptic protein phosphorylation and LTP.
- Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus.
- Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF
Cited by
- Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory.
- A Dietary Supplement Abolishes Age-Related Cognitive Decline in Transgenic Mice Expressing Elevated Free Radical Processes
- Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus.
- Experience‐dependent activation of extracellular signal‐related kinase (ERK) in the olfactory bulb
- Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF.
- The depressive-like behaviors are correlated with decreased phosphorylation of mitogen-activated protein kinases in rat brain following chronic forced swim stress.
- Visual Stimulation Activates ERK in Synaptic and Somatic Compartments of Rat Cortical Neurons with Parallel Kinetics
- Regulation of Hypophysiotrophic Corticotrophin‐Releasing Hormone‐ and Thyrotrophin‐Releasing Hormone‐Synthesising Neurones by Brainstem Catecholaminergic Neurones
- ERK activation and cell growth require CaM kinases in MCF-7 breast cancer cells
- Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory.
- Identification of plasticity‐associated genes regulated by Pavlovian fear conditioning in the lateral amygdala
- DUSP1/MKP‐1 regulates proliferation and apoptosis in keratinocytes through the ERK/Elk‐1/Egr‐1 signaling pathway
- Intercellular Communication and Heterosynaptic Metaplasticity in the Rodent Hippocampus
- Mechanisms Promoting ERK-Dependent Neuronal Oxidative Toxicity
- Investigations into the role of the metabotropic glutamate receptor, mGluR5, in incentive learning and some behavioural and neurobiological effects of cocaine
- Role of nitric oxide and endocannabinoids in synaptic plasticity in the perirhinal cortex and in visual recognition memory
- Diverse Roles for MAPK Signaling in Circadian Clocks
- EFFECTS OF HIV-1 TAT PROTEIN ON STRUCTURE, FUNCTION AND TRAFFICKING OF THE DOPAMINE TRANSPORTER
- Transcription Factors CREB and NF-KB: Involvement in Synaptic Plasticity and Memory Formation
- The effects of hypoxia on neuronal cell signalling.
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