CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers.
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Summary
It is shown that hypoxia synchronously induces tumor CXCL12 and VEGF production and form a synergistic angiogenic axis in vivo, which will be a novel efficient antiangiogenesis strategy to treat cancer.
- Type
- article
- Published
- 2005-01-15
- Cited by
- 438
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W1575688729
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11915000
Keywords
Vascular endothelial growth factor, Cancer research, Ovarian cancer, Medicine, VEGF receptors
References
- Dendritic Cell Subsets Differentially Regulate Angiogenesis in Human Ovarian Cancer
- Role of the Tumor Microenvironment in Mediating Response to Anti-angiogenic Therapy
- A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.
- The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1.
- In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: stromal cell-derived factor-1, steel factor, and the bone marrow environment.
- Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
- Regulation of the production of the RANTES chemokine by endothelial cells. Synergistic induction by IFN-gamma plus TNF-alpha and inhibition by IL-4 and IL-13.
- Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells
- Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma.
- Angiogenesis in cancer and other diseases
- Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
- Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis.
- Macrophage-Derived Dendritic Cells Have Strong Th1-Polarizing Potential Mediated by β-Chemokines Rather Than IL-121
- Optimal Chemotactic Responses of Leukemic T Cells to Stromal Cell-Derived Factor-1 Requires the Activation of Both Class IA and IB Phosphoinositide 3-Kinases1
- Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
- Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
- The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
- Increased immunoreactivity of stromal cell-derived factor‐1 and angiogenesis in asthma
- Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
- Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells.
Cited by
- 17-AAG, a Hsp90 inhibitor, attenuates the hypoxia-induced expression of SDF-1α and ILK in mouse RPE cells
- Managing tumor angiogenesis: lessons from VEGF-resistant tumors and wounds.
- Assessment of the humoral immune response to cancer.
- Etude phénotypique des cellules endométriosiques profondes
- p53 mutation in the genesis of metastasis.
- The use of proteomics techniques to identify potential markers of early stage colorectal cancer
- Lymphocytes T CD4 et immunité anti-tumorale naturelle : impact de la chimiothérapie, émergence de lymphocytes T CD4 cytotoxiques
- Modulation of bone marrow-derived endothelial progenitor cells by vascular endothelial growth inhibitor (VEGI)
- Network biology approaches reveal a link between ribosome biogenesis and metabolic reprogramming in ageing skeletal muscles
- Sonic hedgehog stimulates the recruitment of endothelial progenitor cells.
- Developing novel strategies for treating esophageal cancer: Dendritic cells immunotherapy, T cell responses and an exploration of the tumor microenvironment
- Rôle des progéniteurs dans l’hypertension artérielle pulmonaire humaine et expérimentale
- Regulation of endometrial regeneration; mechanisms contributing to repair and restoration of tissue integrity following menses
- Etude de deux chimiokines CXCL12/SDF-1 et fractalkine (FKN)/CX3CL1 dans le cancer épithélial des ovaires
- The role of the chemokine receptor CXCR4 in EGFRvIII-expressing breast cancer
- Impact d’un gain de fonction de Cxcr4 sur le développement et la compartimentalisation périphérique des lymphocytes
- A novel multi-target cancer therapy based on destabilization of short-lived mRNAs
- MS-275 (ENTINOSTAT) PROMOTES SUSTAINED TUMOR REGRESSION IN THE CONTEXT OF BOOSTING ONCOLYTIC IMMUNOTHERAPY
- Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.
- The inflammatory infiltrate of high-grade serous carcinoma omental metastasis
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