The role of the chemokine receptor CXCR4 in EGFRvIII-expressing breast cancer
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Summary
The ligand-independent, constitutively active Epidermal Growth Fact or Receptor (EGFR) variant, EGFRvIII, is a potent tumor-specific on ogene found in many human cancers, including breast cancer.
- Type
- dissertation
- Published
- 2009-01-01
- Cited by
- 0
- References
- 547
- Access
- Open access
- OpenAlex
- https://openalex.org/W757256760
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:82656517
Keywords
CXCR4, Chemokine receptor, Breast cancer, Chemokine, C-C chemokine receptor type 6
References
- Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor*
- NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4*
- Immunohistochemical analysis of the mutant epidermal growth factor, ΔEGFR, in glioblastoma
- CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells
- A population of very small embryonic-like (VSEL) CXCR4+SSEA-1+Oct-4+ stem cells identified in adult bone marrow
- The shedding of syndecan-4 and syndecan-1 from HeLa cells and human primary macrophages is accelerated by SDF-1/CXCL12 and mediated by the matrix metalloproteinase-9.
- Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2
- Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals
- CXCR4 regulates the early extravasation of metastatic tumor cells in vivo.
- Immunohistochemical Detection of EGFRvIII in High Malignancy Grade Astrocytomas and Evaluation of Prognostic Significance
- Soluble VCAM-1 and E-selectin in breast cancer: relationship with staging and with the detection of circulating cancer cells.
- Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.
- [The role of CXCR4 in lung cancer metastasis and its possible mechanism].
- Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.
- Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells.
- Chemokines, chemokine receptors, and disease
- G Proteins and Calcium Signaling
- Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo.
- CXCR4 and mobilization of hematopoietic precursors.
- Rho GTPases and regulation of hematopoietic stem cell localization.
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