Propeptide-mediated regulation of procollagen synthesis in IMR-90 human lung fibroblast cell cultures. Evidence for transcriptional control.
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Summary
It is concluded that carboxyl-terminal propeptide of type I procollagen can be internalized and become associated with the nuclear compartment, and this suggests a feedback regulatory role onprocollagen synthesis by a direct effect on Procollagen gene transcription.
- Type
- article
- Published
- 1991-02-15
- Cited by
- 51
- References
- 16
- Access
- Open access
- OpenAlex
- https://openalex.org/W1574903262
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29299843
Keywords
Procollagen peptidase, Fibroblast, Protein precursor, Cell biology, Lung
References
- COOH-terminal propeptides of the major human procollagens. Structural, functional and genetic comparisons.
- Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen.
- Transcriptional regulation of type I collagen genes in cultured fibroblasts by a factor isolated from thioacetamide-induced fibrotic rat liver.
- Collagen types in normal and cirrhotic liver.
- Evidence for pretranslational regulation of collagen synthesis by procollagen propeptides.
- Separate amino and carboxyl procollagen peptidases in chick embryo tendon.
- Region-specific initiation of mouse mammary tumor virus RNA synthesis by endogenous RNA polymerase II in preparations of cell nuclei.
- Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.
- Characterization of a new human diploid cell strain, IMR-90.
- Simple and rapid fluorimetric method for DNA microassay.
- Inhibition of procollagen cell-free synthesis by amino-terminal extension peptides.
- Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins.
- Interchain disulfide bonds at the COOH-terminal end of procollagen synthesized by matrix-free cells from chick embryonic tendon and cartilage.
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
- The coordinated regulation of fibrinogen gene transcription by hepatocyte-stimulating factor and dexamethasone
- Binding and uptake of Col 1(I), a peptide capable of inhibiting collagen synthesis in fibroblasts.
Cited by
- Recessive Osteogenesis Imperfecta: Prevalence and Pathophysiology of Collagen Prolyl-3-Hydroxylation Complex Defects
- Cellular Mechanisms in Airways Inflammation
- The type I collagen pro alpha 1(I) COOH-terminal propeptide N-linked oligosaccharide. Functional analysis by site-directed mutagenesis.
- Scar wars strategies. Target collagen.
- The Effect of Carboxyl-Terminal Propeptide of Type I Collagen (c-Propeptide) on Collagen Synthesis of Preosteoblasts and Osteoblasts
- Trimer Carboxyl Propeptide of Collagen I Produced by Mature Osteoblasts Is Chemotactic for Endothelial Cells*
- Molecular characterisation of integrin-procollagen C-propeptide interactions.
- Fibrogenesis in cirrhosis. Potential for therapeutic intervention.
- Biophysical Characterization of the C-propeptide Trimer from Human Procollagen III Reveals a Tri-lobed Structure*
- Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagen.
- Chondrocalcin is internalized by chondrocytes and triggers cartilage destruction via an interleukin-1β-dependent pathway.
- Production and crystallization of the C-propeptide trimer from human procollagen III.
- Increase in expression of Hsp47 and collagen in hereditary gingival fibromatosis is modulated by stress and terminal procollagen N-propeptides.
- Alternatively spliced type II procollagen mRNAs define distinct populations of cells during vertebral development: differential expression of the amino-propeptide
- Novel collagen glomerulopathy in a homotrimeric type I collagen mouse (oim).
- The Globular Domain of the Proα1(I) N-Propeptide Is Not Required for Secretion, Processing by Procollagen N-Proteinase, or Fibrillogenesis of Type I Collagen in Mice*
- In situ expression of collagen and proteoglycan genes in notochord and during skeletal development and growth
- Extracellular matrix remodeling--methods to quantify cell-matrix interactions.
- Decreased Profilaggrin Expression in Ichthyosis Vulgaris Is a Result of Selectively Impaired Posttranscriptional Control (*)
- Structural Basis of Fibrillar Collagen Trimerization and Related Genetic Disorders
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