Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation
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Summary
Preliminary studies have found that IRS-1 and IRS-2 exhibit different expression patterns in both cell lines and human tumors with correlations to patient survival, which provides a potential mechanism for their distinct functions.
- Type
- article
- Published
- 2012-01-01
- Cited by
- 0
- References
- 206
- Access
- Open access
- OpenAlex
- https://openalex.org/W649278390
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:68741399
Keywords
Breast cancer, Insulin receptor, Substrate (aquarium), Insulin, Cancer
References
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- Kinesin associates with anterogradely transported membranous organelles in vivo
- Microtubule Dynamics
- Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.
- Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
- Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation
- Targeting of Integrin β1 and Kinesin 2α by MicroRNA 183*
- Expression and function of IRS-1 in insulin signal transmission.
- Compartmentalization and regulation of insulin signaling to GLUT4 by the cytoskeleton.
- Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.
- Overexpression of Eg5 predicts unfavorable prognosis in non‐muscle invasive bladder urothelial carcinoma
- Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.
- The role of kinesin family proteins in tumorigenesis and progression
- Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free survival.
- Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells.
- Disruption of IRS-2 causes type 2 diabetes in mice
- Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
- Tumor variants by hormone receptor expression in white patients with node-negative breast cancer from the surveillance, epidemiology, and end results database.
- Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation.
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